Technology Process of 2-chloromethyl-1-cyclopropyl-3-fluorobenzene
There total 4 articles about 2-chloromethyl-1-cyclopropyl-3-fluorobenzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
thionyl chloride;
In
dichloromethane;
for 4h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid / 12 h / 80 °C
2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 2.5 h / Inert atmosphere; Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
3.2: 0 - 20 °C
4.1: thionyl chloride / dichloromethane / 4 h / Reflux
With
potassium phosphate; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; water; toluene;
2.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 2.5 h / Inert atmosphere; Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C
2.2: 0 - 20 °C
3.1: thionyl chloride / dichloromethane / 4 h / Reflux
With
potassium phosphate; lithium aluminium tetrahydride; thionyl chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; water; toluene;
1.1: Suzuki Coupling;
