6-bromo-8-(2-cyclopropyl-6-fluoro-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Base Information

Chemical Name:6-bromo-8-(2-cyclopropyl-6-fluoro-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one
CAS No.:1352133-16-4
Molecular Formula:C₁₈H₁₅BrFN₃OS
Molecular Weight:420.305
Hs Code.:

Synonyms:6-bromo-8-(2-cyclopropyl-6-fluoro-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

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Chemical Property of 6-bromo-8-(2-cyclopropyl-6-fluoro-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

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Technology Process of 6-bromo-8-(2-cyclopropyl-6-fluoro-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

There total 6 articles about 6-bromo-8-(2-cyclopropyl-6-fluoro-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1352133-15-3
2-chloromethyl-1-cyclopropyl-3-fluorobenzene

: 352328-87-1
6-bromo-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 1352133-16-4
6-bromo-8-(2-cyclopropyl-6-fluoro-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: 6-bromo-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

2-chloromethyl-1-cyclopropyl-3-fluorobenzene; In N,N-dimethyl-formamide; mineral oil; for 18h;

Reference yield:

: 2252-37-1
2-bromo-6-fluorobenzoic acid

: 1352133-16-4
6-bromo-8-(2-cyclopropyl-6-fluoro-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 12 h / 80 °C

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 2.5 h / Inert atmosphere; Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

3.2: 0 - 20 °C

4.1: thionyl chloride / dichloromethane / 4 h / Reflux

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

5.2: 18 h

With potassium phosphate; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil; 2.1: Suzuki Coupling;

Reference yield:

: 820236-81-5
2-bromo-6-fluorobenzoic acid methyl ester

: 1352133-16-4
6-bromo-8-(2-cyclopropyl-6-fluoro-benzyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 2.5 h / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

2.2: 0 - 20 °C

3.1: thionyl chloride / dichloromethane / 4 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

4.2: 18 h

With potassium phosphate; lithium aluminium tetrahydride; thionyl chloride; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: Suzuki Coupling;