6-(2-chloro-6-fluorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde

Base Information

Chemical Name:6-(2-chloro-6-fluorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde
CAS No.:1452231-33-2
Molecular Formula:C₁₅H₉ClFN₃O₂S
Molecular Weight:349.773
Hs Code.:

Synonyms:6-(2-chloro-6-fluorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde

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Chemical Property of 6-(2-chloro-6-fluorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde

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Technology Process of 6-(2-chloro-6-fluorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde

There total 3 articles about 6-(2-chloro-6-fluorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1452231-32-1
N-(2-chloro-6-fluorophenyl)-4-methyl-2-(methylthio)pyrimidine-5-carboxamide

: 3724-43-4,149409-22-3
Vilsmeier reagent

: 1452231-33-2
6-(2-chloro-6-fluorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 98276-75-6
4-methyl-2-(methylthio)pyrimidine-5-carboxylic acid

: 1452231-33-2
6-(2-chloro-6-fluorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / 1,4-dioxane / 0.5 h / 20 °C

1.2: 100 °C

2.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With thionyl chloride; N,N-dimethyl-formamide; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 7234-25-5
4-methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester

: 1452231-33-2
6-(2-chloro-6-fluorophenyl)-2-(methylthio)-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidine-8-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / tetrahydrofuran; methanol / 12 h / 20 °C

2.1: N,N-dimethyl-formamide; thionyl chloride / 1,4-dioxane / 0.5 h / 20 °C

2.2: 100 °C

3.1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With thionyl chloride; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;