N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-ethyl-2,3-dioxopiperazine-1-carboxamide

Base Information

Chemical Name:N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-ethyl-2,3-dioxopiperazine-1-carboxamide
CAS No.:1364569-87-8
Molecular Formula:C₂₅H₂₅N₅O₄S
Molecular Weight:491.571
Hs Code.:

Synonyms:N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-ethyl-2,3-dioxopiperazine-1-carboxamide

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Chemical Property of N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-ethyl-2,3-dioxopiperazine-1-carboxamide

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Technology Process of N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-ethyl-2,3-dioxopiperazine-1-carboxamide

There total 5 articles about N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-ethyl-2,3-dioxopiperazine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1364569-75-4
4-ethyl-N-(4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-2,3-dioxopiperazine-1-carboxamide

: 1364569-87-8
N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-ethyl-2,3-dioxopiperazine-1-carboxamide

Guidance literature:: With tin(II) chloride dihdyrate; ammonium acetate; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmcl.2012.01.053

Reference yield:

: 33233-67-9
4-(tert-Butoxycarbonylaminomethyl)benzoic acid

: 1364569-87-8
N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-ethyl-2,3-dioxopiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / pyridine / 3 h / 20 °C / Inert atmosphere

2: pyridine; N,N-dimethyl-formamide / 20 °C

3: hydrogenchloride / tetrahydrofuran; methanol; water / 20 °C

4: triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

5: tin(II) chloride dihdyrate; ammonium acetate / tetrahydrofuran; methanol / 20 °C

With hydrogenchloride; oxalyl dichloride; tin(II) chloride dihdyrate; ammonium acetate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.053

Reference yield:

: 1364569-59-4
tert-butyl 4-(2-nitro-5-(thiophen-2-yl)phenylcarbamoyl)benzylcarbamate

: 1364569-87-8
N-(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzyl)-4-ethyl-2,3-dioxopiperazine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / tetrahydrofuran; methanol; water / 20 °C

2: triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C

3: tin(II) chloride dihdyrate; ammonium acetate / tetrahydrofuran; methanol / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; ammonium acetate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.053