Technology Process of (6R)-1-iodo-5,5-dimethyl-6-pentylcyclohex-1-ene
There total 4 articles about (6R)-1-iodo-5,5-dimethyl-6-pentylcyclohex-1-ene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
dipentylzinc;
With
CuCN*2LiCl;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one;
at -30 ℃;
for 0.5h;
phosphoric acid diethyl ester (R)-2-iodo-4,4-dimethylcyclohex-2-enyl ester;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one;
at -30 - -10 ℃;
for 15h;
Further stages.;
DOI:10.1002/anie.200600247
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / PDC; I2 / CH2Cl2 / 51 h / 20 °C
2: 90 percent / L-diphenylprolinol; B(OMe)3; borane-N,N-diethylaniline complex / tetrahydrofuran / 1 h / 20 °C
3: 85 percent / N-methylimidazole / diethyl ether / 16 h / 20 °C
4: 80 percent / CuCN*2LiCl / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 15 h / -30 - -10 °C
With
1-methyl-1H-imidazole; dipyridinium dichromate; borane N,N-diethylaniline complex; (R)-diphenylprolinol; Trimethyl borate; iodine;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; dichloromethane;
DOI:10.1021/ol049221q
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90 percent / L-diphenylprolinol; B(OMe)3; borane-N,N-diethylaniline complex / tetrahydrofuran / 1 h / 20 °C
2: 85 percent / N-methylimidazole / diethyl ether / 16 h / 20 °C
3: 80 percent / CuCN*2LiCl / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 15 h / -30 - -10 °C
With
1-methyl-1H-imidazole; borane N,N-diethylaniline complex; (R)-diphenylprolinol; Trimethyl borate;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether;
DOI:10.1021/ol049221q
