1,1-dimethylethyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-indol-4-yl}oxy)-1-piperidinecarboxylate
CAS No.:1001397-85-8
Molecular Formula:C₂₅H₂₉FN₂O₅S
Molecular Weight:488.58
Hs Code.:

Synonyms:1,1-dimethylethyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

There total 5 articles about 1,1-dimethylethyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-indol-4-yl}oxy)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1001397-85-8
1,1-dimethylethyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:

Reference yield:

: 1001397-84-7
1,1-dimethylethyl 4-{[1-(4-bromo-2-fluorophenyl)-1H-indol-4-yl]oxy}-1-piperidinecarboxylate

: 20277-69-4
sodium methansulfinate

: 1001397-85-8
1,1-dimethylethyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: With copper(l) iodide; L-proline; sodium hydroxide; In dimethyl sulfoxide; at 110 ℃; for 18h; Sealed tube;
DOI:10.1021/jm301404a

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1001397-85-8
1,1-dimethylethyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 8 h / 5 - 20 °C / Inert atmosphere

2: copper(l) iodide; potassium phosphate; (1R,2R)-1,2-diaminocyclohexane / 15 h / 20 °C / Inert atmosphere; Reflux

3: copper(l) iodide; L-proline; sodium hydroxide / dimethyl sulfoxide / 18 h / 110 °C / Sealed tube

With potassium phosphate; copper(l) iodide; di-isopropyl azodicarboxylate; (1R,2R)-1,2-diaminocyclohexane; triphenylphosphine; L-proline; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jm301404a