methyl (1S,2R)-cis-2-<<<2-(benzyloxyamino)-2-oxoethyl>methylamino>carbonyl>cyclohexanecarboxylate

Base Information

Chemical Name:methyl (1S,2R)-cis-2-<<<2-(benzyloxyamino)-2-oxoethyl>methylamino>carbonyl>cyclohexanecarboxylate
CAS No.:127387-87-5
Molecular Formula:C₁₉H₂₆N₂O₅
Molecular Weight:362.426
Hs Code.:

Synonyms:methyl (1S,2R)-cis-2-<<<2-(benzyloxyamino)-2-oxoethyl>methylamino>carbonyl>cyclohexanecarboxylate

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Chemical Property of methyl (1S,2R)-cis-2-<<<2-(benzyloxyamino)-2-oxoethyl>methylamino>carbonyl>cyclohexanecarboxylate

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Technology Process of methyl (1S,2R)-cis-2-<<<2-(benzyloxyamino)-2-oxoethyl>methylamino>carbonyl>cyclohexanecarboxylate

There total 4 articles about methyl (1S,2R)-cis-2-<<<2-(benzyloxyamino)-2-oxoethyl>methylamino>carbonyl>cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2-(methylamino)-N-(benzyloxy)acetamide hydrochloride

: 147201-81-8
(1R,2S)-cis-2-(methoxycarbonyl)cyclohexanecarbonyl chloride

: 127387-87-5
methyl (1S,2R)-cis-2-<<<2-(benzyloxyamino)-2-oxoethyl>methylamino>carbonyl>cyclohexanecarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 5 ℃;
DOI:10.1021/jm00058a006

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 127387-87-5
methyl (1S,2R)-cis-2-<<<2-(benzyloxyamino)-2-oxoethyl>methylamino>carbonyl>cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / triethylamine, 1,3-dicyclohexylcarbodiimide / CHCl₃ / Ambient temperature

2: 78.5 percent / HCl gas / ethyl acetate / 2 h / 0 °C

3: 90 percent / NEt₃ / CH₂Cl₂ / 0 - 5 °C

With hydrogenchloride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; ethyl acetate;
DOI:10.1021/jm00058a006

Reference yield:

: 137022-79-8
2-(BOC-methylamino)-N-(benzyloxy)acetamide

: 127387-87-5
methyl (1S,2R)-cis-2-<<<2-(benzyloxyamino)-2-oxoethyl>methylamino>carbonyl>cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 78.5 percent / HCl gas / ethyl acetate / 2 h / 0 °C

2: 90 percent / NEt₃ / CH₂Cl₂ / 0 - 5 °C

With hydrogenchloride; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00058a006