1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine

Base Information

• Chemical Name: 1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine
• CAS No.: 1380167-26-9
• Molecular Formula: C₂₆H₃₆BrN₅O₁₀S₂
• Molecular Weight: 722.635
• Mol file: 1380167-26-9.mol

Synonyms:1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine

Chemical Property of 1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine

There total 4 articles about 1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C25H41BrN4O8S + 1,3-dibromo-propane (109-64-8) → 1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine (1380167-26-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 0 - 20 ℃; for 13h;

DOI:10.1039/c3cc45213a

Reference yield: 72.0%

1-N-Boc-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine (1380167-25-8) + 1,3-dibromo-propane (109-64-8) → 1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine (1380167-26-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 8.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.04.009

Reference yield:

bis(3-aminopropyl)amine (56-18-8) → 1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine (1380167-26-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 24 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 8.5 h / 0 - 20 °C / Inert atmosphere

With potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.04.009

upstream raw materials:

bis(3-aminopropyl)amine

1-N-Boc-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine

1,3-dibromo-propane

Downstream raw materials:

C₃₂H₄₂N₈O₁₂S₂

C₃₁H₄₀N₁₀O₁₀S₂

C₃₈H₄₅N₇O₁₃S₂

C₃₇H₄₃N₇O₁₃S₂