2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylamide

Base Information

Chemical Name:2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylamide
CAS No.:1350473-38-9
Molecular Formula:C₂₂H₃₄N₄O₂Si
Molecular Weight:414.623
Hs Code.:

Synonyms:2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylamide

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Chemical Property of 2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylamide

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Technology Process of 2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylamide

There total 7 articles about 2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185428-39-0
2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

: 108-91-8,157973-60-9
cyclohexylamine

: 1350473-38-9
2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylamide

Guidance literature:: 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 60 ℃; for 0.75h;

cyclohexylamine; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield:

: 1334674-88-2
(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1350473-38-9
2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Jones reagent / water; acetone

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

2.2: 1 h / 0 - 20 °C

3.1: tricyclohexylphosphine; potassium phosphate / palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

4.1: water; aminosulfonic acid; potassium dihydrogenphosphate; sodium chloride / 1,4-dioxane / 2 h / 20 °C

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.75 h / 60 °C

5.2: 1.5 h / 20 °C

With potassium phosphate; potassium dihydrogenphosphate; Jones reagent; aminosulfonic acid; water; sodium hydride; 1,1'-carbonyldiimidazole; sodium chloride; tricyclohexylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil;

Reference yield:

: 1334674-87-1
(2-bromo-5-hydroxymethyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1350473-38-9
2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

1.2: pH 4

2.1: Jones reagent / water; acetone

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

3.2: 1 h / 0 - 20 °C

4.1: tricyclohexylphosphine; potassium phosphate / palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

5.1: water; aminosulfonic acid; potassium dihydrogenphosphate; sodium chloride / 1,4-dioxane / 2 h / 20 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.75 h / 60 °C

6.2: 1.5 h / 20 °C

With potassium phosphate; potassium dihydrogenphosphate; Jones reagent; aminosulfonic acid; water; sodium hydride; 1,1'-carbonyldiimidazole; sodium chloride; sodium hydroxide; tricyclohexylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil;