(2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Base Information

Chemical Name:(2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol
CAS No.:329359-47-9
Molecular Formula:C₄₉H₇₄O₁₁Si
Molecular Weight:867.205
Hs Code.:

(2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Synonyms:(2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Suppliers and Price of (2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

There total 16 articles about (2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: ((2R,4S,6R,8S,10S)-8-{(2R,3R)-2-Benzyloxymethoxy-3-[(4S,5R)-2-(3,4-dimethoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-butyl}-2-benzyloxymethyl-10-methoxy-1,7-dioxa-spiro[5.5]undec-4-yloxy)-tert-butyl-dimethyl-silane

: 329359-47-9
(2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 - 0 ℃;
DOI:10.1002/1521-3773(20010105)40:1<191::AID-ANIE191>3.0.CO;2-C

Reference yield:

: (2S,4S)-5-[2-((2S,4R)-5-Benzyloxy-2,4-dihydroxy-pentyl)-[1,3]dithian-2-yl]-4-methoxy-pentane-1,2-diol

: 329359-47-9
(2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 11 steps

1.1: Hg(ClO₄)2; CaCO₃ / acetonitrile; H₂O

2.1: HClO₄ / CH₂Cl₂; acetonitrile

3.1: 87 percent / Et₃N / CH₂Cl₂

4.1: 99 percent / imidazole / dimethylformamide

5.1: 100 percent / DIBAL / CH₂Cl₂ / -78 °C

6.1: 90 percent / I₂; PPh₃; imidazole / benzene

7.1: t-BuLi; HMPA / tetrahydrofuran / -78 °C

7.2: 95 percent / tetrahydrofuran / -78 - 0 °C

8.1: 71 percent / Hg(ClO₄)2; CaCO₃ / methanol; H₂O / 0 °C

9.1: NaBH₄ / methanol; CH₂Cl₂

10.1: 94 percent / iPr₂NEt / CH₂Cl₂

11.1: 78 percent / DIBAL / toluene; various solvent(s) / -78 - 0 °C

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; perchloric acid; mercury(II) perchlorate; iodine; tert.-butyl lithium; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1002/1521-3773(20010105)40:1<191::AID-ANIE191>3.0.CO;2-C

Reference yield:

: 201275-41-4
(S)-4-((S)-3-{2-[(2S,4R)-5-Benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-pentyl]-[1,3]dithian-2-yl}-2-methoxy-propyl)-2,2-dimethyl-[1,3]dioxolane

: 329359-47-9
(2R,3S,4R,5R)-5-Benzyloxymethoxy-6-[(2S,4S,6R,8R,10S)-8-benzyloxymethyl-10-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-1,7-dioxa-spiro[5.5]undec-2-yl]-3-(3,4-dimethoxy-benzyloxy)-2,4-dimethyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 12 steps

1.1: 85 percent / HCl / methanol

2.1: Hg(ClO₄)2; CaCO₃ / acetonitrile; H₂O

3.1: HClO₄ / CH₂Cl₂; acetonitrile

4.1: 87 percent / Et₃N / CH₂Cl₂

5.1: 99 percent / imidazole / dimethylformamide

6.1: 100 percent / DIBAL / CH₂Cl₂ / -78 °C

7.1: 90 percent / I₂; PPh₃; imidazole / benzene

8.1: t-BuLi; HMPA / tetrahydrofuran / -78 °C

8.2: 95 percent / tetrahydrofuran / -78 - 0 °C

9.1: 71 percent / Hg(ClO₄)2; CaCO₃ / methanol; H₂O / 0 °C

10.1: NaBH₄ / methanol; CH₂Cl₂

11.1: 94 percent / iPr₂NEt / CH₂Cl₂

12.1: 78 percent / DIBAL / toluene; various solvent(s) / -78 - 0 °C

With 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; perchloric acid; mercury(II) perchlorate; iodine; tert.-butyl lithium; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;
DOI:10.1002/1521-3773(20010105)40:1<191::AID-ANIE191>3.0.CO;2-C