5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole

Base Information

Chemical Name:5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole
CAS No.:222835-56-5
Molecular Formula:C₄₀H₃₇ClN₂O₅
Molecular Weight:661.197
Hs Code.:

Synonyms:5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole

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Chemical Property of 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole

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Technology Process of 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole

There total 9 articles about 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 222835-55-4
N-(tert-butyloxycarbonyl)-N-(3-chloro-2-propen-1-yl)-6-(9-fluorenylmethyloxy-carbonylamino)-4-benzyloxy-1-iodo-2-naphthylamine

: 222835-56-5
5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 15h; Heating;
DOI:10.1039/a807884j

Reference yield:

: 222535-06-0
4-benzyloxy-6-nitro-2-naphthalenecarboxylic acid

: 222835-56-5
5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; diphenyl phosphoryl azide / 24 h / Molecular sieve; Reflux

2: sulfuric acid; 2-iodocyclopentane-1,3-dione / tetrahydrofuran; methanol

3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrazine hydrate; iron(III) chloride / tetrahydrofuran; methanol

5: dmap / tetrahydrofuran

6: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / benzene

With 2-iodocyclopentane-1,3-dione; dmap; iron(III) chloride; 2,2'-azobis(isobutyronitrile); sulfuric acid; diphenyl phosphoryl azide; tri-n-butyl-tin hydride; sodium hydride; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;

Reference yield:

: 222535-07-1
N-(tert-butyloxycarbonyl)-4-benzyloxy-6-nitro-2-naphthylamine

: 222835-56-5
5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-chloromethyl-7-(9-fluorenylmethyloxy-carbonylamino)-1,2-dihydro-3H-benz[e]indole

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; 2-iodocyclopentane-1,3-dione / tetrahydrofuran; methanol

2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrazine hydrate; iron(III) chloride / tetrahydrofuran; methanol

4: dmap / tetrahydrofuran

5: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / benzene

With 2-iodocyclopentane-1,3-dione; dmap; iron(III) chloride; 2,2'-azobis(isobutyronitrile); sulfuric acid; tri-n-butyl-tin hydride; sodium hydride; hydrazine hydrate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;