methyl (2S,3R,1′S,αS)-2-(1′-phenylprop-2′-en-1′-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Base Information

Chemical Name:methyl (2S,3R,1′S,αS)-2-(1′-phenylprop-2′-en-1′-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate
CAS No.:1596359-57-7
Molecular Formula:C₃₄H₃₅NO₂
Molecular Weight:489.657
Hs Code.:

Synonyms:methyl (2S,3R,1′S,αS)-2-(1′-phenylprop-2′-en-1′-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

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Chemical Property of methyl (2S,3R,1′S,αS)-2-(1′-phenylprop-2′-en-1′-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

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Technology Process of methyl (2S,3R,1′S,αS)-2-(1′-phenylprop-2′-en-1′-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

There total 11 articles about methyl (2S,3R,1′S,αS)-2-(1′-phenylprop-2′-en-1′-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1596359-55-5
C₃₃H₃₃NO₂

: 74-88-4
methyl iodide

: 1596359-57-7
methyl (2S,3R,1′S,αS)-2-(1′-phenylprop-2′-en-1′-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 16h; diastereoselective reaction; Inert atmosphere;
DOI:10.1039/c4ob00274a

Reference yield:

: 1596359-56-6
C₃₃H₃₃NO₂

: 74-88-4
methyl iodide

: 1596359-57-7
methyl (2S,3R,1′S,αS)-2-(1′-phenylprop-2′-en-1′-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

: 1596359-58-8
C₃₄H₃₅NO₂

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 16h; diastereoselective reaction; Inert atmosphere;
DOI:10.1039/c4ob00274a

Reference yield:

: 265669-72-5
tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

: 1596359-57-7
methyl (2S,3R,1′S,αS)-2-(1′-phenylprop-2′-en-1′-yl)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

1.3: 16 h / 0 - 20 °C / Inert atmosphere

2.1: chloro-trimethyl-silane / toluene / 0.17 h / -78 °C / Inert atmosphere

2.2: 1.25 h / -78 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 16 h / 20 °C / Inert atmosphere

With chloro-trimethyl-silane; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In dichloromethane; toluene; acetonitrile;
DOI:10.1039/c4ob00274a