Caesium; 4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: Caesium; 4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carboxylate
• CAS No.: 77716-12-2
• Molecular Formula: C₁₁H₁₅N₂O₄*Cs
• Molecular Weight: 372.156
• Mol file: 77716-12-2.mol

Synonyms:Caesium; 4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carboxylate

Chemical Property of Caesium; 4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Caesium; 4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carboxylate

There total 4 articles about Caesium; 4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(tert-butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid (77716-11-1) → Caesium; 4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carboxylate (77716-12-2)

Guidance literature:

With caesium carbonate; In ethanol; water;

DOI:10.1021/jo00330a022

Reference yield:

1-methyl-4-nitro-pyrrol-2-carboxylic acid (13138-78-8) → Caesium; 4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carboxylate (77716-12-2)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂, 1.0 M Na₂CO₃(aq.) / 5percent Pd/C / 3.5 h / 3102.9 Torr / Ambient temperature

2: tetrahydrofuran; diethyl ether / 1.) 1 h, ice cooled, 2.) 2 h, ambient temperature

3: Cs₂CO₃ / ethanol; H₂O

With hydrogen; sodium carbonate; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water;

DOI:10.1021/jo00330a022

Reference yield:

ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate (2853-29-4) → Caesium; 4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carboxylate (77716-12-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 69 percent / 2 M NaOH / ethanol / 1.5 h / Heating

2: H₂, 1.0 M Na₂CO₃(aq.) / 5percent Pd/C / 3.5 h / 3102.9 Torr / Ambient temperature

3: tetrahydrofuran; diethyl ether / 1.) 1 h, ice cooled, 2.) 2 h, ambient temperature

4: Cs₂CO₃ / ethanol; H₂O

With sodium hydroxide; hydrogen; sodium carbonate; caesium carbonate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water;

DOI:10.1021/jo00330a022

upstream raw materials:

4-[(tert-butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid

4-amino-1-methylpyrrole-2-carboxylic acid

1-methyl-4-nitro-pyrrol-2-carboxylic acid

ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate

Downstream raw materials:

Benzyl 4-<<<4-<<<4-(Formylamino)-1-methylpyrrol-2-yl>carbonyl>amino>-1-methylpyrrol-2-yl>carbonyl>amino>-1-methylpyrrole-2-carboxylate

benzyl 4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylate

Benzyl 4-<<(4-Amino-1-methylpyrrol-2-yl)carbonyl>amino>-1-methylpyrrole-2-carboxylate

Benzyl 4-Amino-1-methylpyrrole-2-carboxylate