5-phenyl-2-phenylethynyl-pyridine-3-carbonitrile

Base Information

• Chemical Name: 5-phenyl-2-phenylethynyl-pyridine-3-carbonitrile
• CAS No.: 1100051-11-3
• Molecular Formula: C₂₀H₁₂N₂
• Molecular Weight: 280.329
• Mol file: 1100051-11-3.mol

Synonyms:5-phenyl-2-phenylethynyl-pyridine-3-carbonitrile

Chemical Property of 5-phenyl-2-phenylethynyl-pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 5-phenyl-2-phenylethynyl-pyridine-3-carbonitrile

There total 1 articles about 5-phenyl-2-phenylethynyl-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-phenyl-2-chloropyridine-3-carbonitrile (10177-10-3) + phenylacetylene (536-74-3) → 5-phenyl-2-phenylethynyl-pyridine-3-carbonitrile (1100051-11-3)

Guidance literature:

With triethylamine; triphenylphosphine; palladium dichloride; In acetonitrile; at 80 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tet.2008.10.010

Reference yield: 90.0%

5-phenyl-2-phenylethynyl-pyridine-3-carbonitrile (1100051-11-3) → 2-(2-chloro-2-phenylvinyl)-5-phenylnicotinonitrile

Guidance literature:

With trichlorophosphate; In neat (no solvent); at 80 ℃; for 2h; stereoselective reaction;

DOI:10.1039/c9ob00841a

Reference yield: 83.0%

methanol (67-56-1) + 5-phenyl-2-phenylethynyl-pyridine-3-carbonitrile (1100051-11-3) → 7-benzylidene-5-methoxy-3-phenyl-7H-pyrrolo[3,4-b]pyridine

Guidance literature:

With copper(l) iodide; potassium carbonate; triphenylphosphine; at 80 ℃; for 7h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.9b00662

upstream raw materials:

5-phenyl-2-chloropyridine-3-carbonitrile

phenylacetylene

Refernces

• 1、 Singh, Radhey M.,Kumar, Ritush,Sharma, Neha,Asthana, Mrityunjaya. "Palladium-catalyzed one-pot synthesis of benzo[b][1,6]naphthyridines via Sonogashira coupling and annulation reactions from 2-chloroquinoline-3- carbonitriles". . p. 9443 - 9450. Retrieved 2013/10/08.