(S)-1-(4-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

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Chemical Name:(S)-1-(4-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione
CAS No.:1204659-13-1
Molecular Formula:C₂₅H₂₅F₂N₃O₄
Molecular Weight:469.488
Hs Code.:

Synonyms:(S)-1-(4-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

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Chemical Property of (S)-1-(4-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

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Technology Process of (S)-1-(4-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

There total 2 articles about (S)-1-(4-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 131180-45-5
(S)-α,α-Bis(4-fluorophenyl)-2-pyrrolidinemethanol

: 2950-83-6
4-(2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl)butanoic acid

: 1204659-13-1
(S)-1-(4-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm201627n

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1204659-13-1
(S)-1-(4-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / 0 °C

2: methanol; potassium hydroxide / 12 h / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 3 h / 20 °C

With methanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm201627n