(S)-ALPHA,ALPHA-BIS(4-FLUOROPHENYL)-2-PYRROLIDINEMETHANOL

Base Information

• Chemical Name: (S)-ALPHA,ALPHA-BIS(4-FLUOROPHENYL)-2-PYRROLIDINEMETHANOL
• CAS No.: 131180-45-5
• Molecular Formula: C17H17 F2 N O
• Molecular Weight: 289.3197864
• Hs Code.: 2933990090
• Mol file: 131180-45-5.mol

Synonyms:2-Pyrrolidinemethanol,a,a-bis(4-fluorophenyl)-, (S)-

Chemical Property of (S)-ALPHA,ALPHA-BIS(4-FLUOROPHENYL)-2-PYRROLIDINEMETHANOL

Chemical Property:

• PSA: 32.26000
• LogP: 3.28150

Purity/Quality:

98% ^*data from raw suppliers

2-Pyrrolidinemethanol,a,a-bis(4-fluorophenyl)-,(2S)- 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-ALPHA,ALPHA-BIS(4-FLUOROPHENYL)-2-PYRROLIDINEMETHANOL

There total 6 articles about (S)-ALPHA,ALPHA-BIS(4-FLUOROPHENYL)-2-PYRROLIDINEMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-ethyl 2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate → (S)-α,α-Bis(4-fluorophenyl)-2-pyrrolidinemethanol (131180-45-5)

Guidance literature:

With methanol; potassium hydroxide; for 12h; Reflux;

DOI:10.1021/jm201627n

Reference yield: 89.5%

(S)-proline-N-carboxyanhydride (45736-33-2) + 4-flourophenylmagnesium bromide (352-13-6) → (S)-α,α-Bis(4-fluorophenyl)-2-pyrrolidinemethanol (131180-45-5)

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/jo00002a049

Reference yield:

(S)-proline-N-ethyl carbamate methyl ester (77581-28-3,93423-88-2) → (S)-α,α-Bis(4-fluorophenyl)-2-pyrrolidinemethanol (131180-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: KOH / methanol / 4 h

With potassium hydroxide; In tetrahydrofuran; methanol; 1: Grignard reaction;

DOI:10.1016/S0957-4166(02)00789-9

upstream raw materials:

(S)-proline-N-carboxyanhydride

4-flourophenylmagnesium bromide

(S)-proline-N-ethyl carbamate methyl ester

L-proline

Downstream raw materials:

(S)-1-(4-(2-(bis(4-fluorophenyl)(hydroxy)methyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione