(S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride

Base Information

Chemical Name:(S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride
CAS No.:68800-28-2
Molecular Formula:C₁₈H₂₆N₄O₅S*ClH
Molecular Weight:446.955
Hs Code.:

Synonyms:(S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride

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Chemical Property of (S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride

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Technology Process of (S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride

There total 4 articles about (S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61543-56-4
boc-Phe-Met-OH

: 68800-28-2
(S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 2N HCl / acetic acid / 0.33 h

2: 1.) 4-hydroxy-3-nitrobenzophenone fixed to a polystyrene matrix, 2.) triethylamine / 2.) DMF, 20 min

3: 2N HCl / acetic acid

With hydrogenchloride; (4-hydroxy-3-nitrophenyl)(phenyl)methanone; triethylamine; In acetic acid;
DOI:10.1007/BF00597660

Reference yield:

: 62530-45-4
(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid; hydrochloride

: 68800-28-2
(S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 4-hydroxy-3-nitrobenzophenone fixed to a polystyrene matrix, 2.) triethylamine / 2.) DMF, 20 min

2: 2N HCl / acetic acid

With hydrogenchloride; (4-hydroxy-3-nitrophenyl)(phenyl)methanone; triethylamine; In acetic acid;
DOI:10.1007/BF00597660

Reference yield:

: 63-68-3,26062-47-5,58576-49-1
L-methionine

: 68800-28-2
(S)-2-{(S)-2-[2-(2-Amino-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / aq. 1N NaOH / dioxane / 24 h / Ambient temperature

2: 2N HCl / acetic acid / 0.33 h

3: 1.) 4-hydroxy-3-nitrobenzophenone fixed to a polystyrene matrix, 2.) triethylamine / 2.) DMF, 20 min

4: 2N HCl / acetic acid

With hydrogenchloride; sodium hydroxide; (4-hydroxy-3-nitrophenyl)(phenyl)methanone; triethylamine; In 1,4-dioxane; acetic acid;
DOI:10.1007/BF00597660