8-diethoxyphosphoryl-4,12-bis(p-toluenesulfonyl)-1-oxa-4,8,12-triazacyclotetradecane

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Chemical Name:8-diethoxyphosphoryl-4,12-bis(p-toluenesulfonyl)-1-oxa-4,8,12-triazacyclotetradecane
CAS No.:247210-70-4
Molecular Formula:C₂₈H₄₄N₃O₈PS₂
Molecular Weight:645.778
Hs Code.:

Synonyms:8-diethoxyphosphoryl-4,12-bis(p-toluenesulfonyl)-1-oxa-4,8,12-triazacyclotetradecane

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Chemical Property of 8-diethoxyphosphoryl-4,12-bis(p-toluenesulfonyl)-1-oxa-4,8,12-triazacyclotetradecane

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Technology Process of 8-diethoxyphosphoryl-4,12-bis(p-toluenesulfonyl)-1-oxa-4,8,12-triazacyclotetradecane

There total 4 articles about 8-diethoxyphosphoryl-4,12-bis(p-toluenesulfonyl)-1-oxa-4,8,12-triazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 5414-19-7
1,1'-oxybis(2-bromo-ethane)

: 247210-69-1
N-diethoxyphosphoryl-N',N''-bis(p-toluenesulfonyl)-3,3'-iminobis[propylamine]

: 247210-70-4
8-diethoxyphosphoryl-4,12-bis(p-toluenesulfonyl)-1-oxa-4,8,12-triazacyclotetradecane

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 24h;
DOI:10.1021/jm990211i

Reference yield:

: 111-94-4
3,3'-Iminodipropionitrile

: 247210-70-4
8-diethoxyphosphoryl-4,12-bis(p-toluenesulfonyl)-1-oxa-4,8,12-triazacyclotetradecane

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 92 percent / H₂, NH₃ / Raney nickel / methanol / 48 h / 20 °C / 2327.17 Torr

3: 43 percent / Et₃N / CH₂Cl₂ / 20 °C

4: 79 percent / Cs₂CO₃ / dimethylformamide / 24 h / 65 °C

With ammonia; hydrogen; caesium carbonate; triethylamine; nickel; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: protection of the amino group / 2: Hydrogenation / 3: Tosylation / 4: cyclocondensation;
DOI:10.1021/jm990211i

Reference yield:

: 90974-12-2
N-diethoxyphosphoryl-3,3'-iminodipropionitrile

: 247210-70-4
8-diethoxyphosphoryl-4,12-bis(p-toluenesulfonyl)-1-oxa-4,8,12-triazacyclotetradecane

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂, NH₃ / Raney nickel / methanol / 48 h / 20 °C / 2327.17 Torr

2: 43 percent / Et₃N / CH₂Cl₂ / 20 °C

3: 79 percent / Cs₂CO₃ / dimethylformamide / 24 h / 65 °C

With ammonia; hydrogen; caesium carbonate; triethylamine; nickel; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Hydrogenation / 2: Tosylation / 3: cyclocondensation;
DOI:10.1021/jm990211i