8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester 5-oxide

Base Information

Chemical Name:8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester 5-oxide
CAS No.:77132-93-5
Molecular Formula:C₂₁H₁₇ClFN₃O₃
Molecular Weight:413.836
Hs Code.:

Synonyms:8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester 5-oxide

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Chemical Property of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester 5-oxide

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Technology Process of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester 5-oxide

There total 3 articles about 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester 5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77132-80-0
7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-ylideneacetic acid ethyl ester 4-oxide

: 77132-93-5
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester 5-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

With acetic acid; sodium nitrite;
DOI:10.1002/jhet.5570230509

Reference yield:

: 60656-74-8
6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide

: 77132-93-5
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester 5-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 1) lithium diisopropylamide / 1) hexane, tetrahydrofuran, -50 to -45 deg C 2) warming to room temperature, 2 h

2: 78 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

With acetic acid; lithium diisopropyl amide; sodium nitrite;
DOI:10.1002/jhet.5570230509