trimethoxy[[dimethyl(2,4,6-trimethoxyphenyl)silyl]methyl]silane

Base Information

• Chemical Name: trimethoxy[[dimethyl(2,4,6-trimethoxyphenyl)silyl]methyl]silane
• CAS No.: 1440146-78-0
• Molecular Formula: C₁₅H₂₈O₆Si₂
• Molecular Weight: 360.555
• Mol file: 1440146-78-0.mol

Synonyms:trimethoxy[[dimethyl(2,4,6-trimethoxyphenyl)silyl]methyl]silane

Chemical Property of trimethoxy[[dimethyl(2,4,6-trimethoxyphenyl)silyl]methyl]silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of trimethoxy[[dimethyl(2,4,6-trimethoxyphenyl)silyl]methyl]silane

There total 2 articles about trimethoxy[[dimethyl(2,4,6-trimethoxyphenyl)silyl]methyl]silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

tetramethylorthosilicate (681-84-5) + (chloromethyl)dimethyl(2,4,6-trimethoxyphenyl)silane (1253730-12-9) → trimethoxy[[dimethyl(2,4,6-trimethoxyphenyl)silyl]methyl]silane (1440146-78-0)

Guidance literature:

(chloromethyl)dimethyl(2,4,6-trimethoxyphenyl)silane; With magnesium; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

tetramethylorthosilicate; In tetrahydrofuran; at 20 ℃; for 17h; Inert atmosphere; Reflux;

DOI:10.1021/om400190q

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) → trimethoxy[[dimethyl(2,4,6-trimethoxyphenyl)silyl]methyl]silane (1440146-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / pentane; hexane / 3.5 h / 0 - 20 °C / Inert atmosphere

1.2: 18 h / 0 - 20 °C / Inert atmosphere

2.1: magnesium / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2.2: 17 h / 20 °C / Inert atmosphere; Reflux

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; magnesium; In tetrahydrofuran; hexane; pentane;

DOI:10.1021/om400190q

Reference yield: 58.0%

methanol (67-56-1) + trimethoxy[[dimethyl(2,4,6-trimethoxyphenyl)silyl]methyl]silane (1440146-78-0) → 1,2,3-trimethoxybenzene (621-23-8) + methoxydimethyl[(trimethoxysilyl)methyl]silane (1440146-57-5)

Guidance literature:

With trifluoroacetic acid; In diethyl ether; at 0 - 20 ℃; for 0.5h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/om400190q

upstream raw materials:

tetramethylorthosilicate

(chloromethyl)dimethyl(2,4,6-trimethoxyphenyl)silane

1,2,3-trimethoxybenzene

Downstream raw materials:

1,2,3-trimethoxybenzene

chlorodimethyl[(trimethoxysilyl)methyl]silane

methylbis(2,4,6-trimethoxyphenyl)[(trimethylsilyl)methyl]silane

(chloromethyl)methylbis(2,4,6-trimethoxyphenyl)silane