4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-methylsulfonyloxybutane

Base Information

• Chemical Name: 4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-methylsulfonyloxybutane
• CAS No.: 958851-00-8
• Molecular Formula: C₁₈H₁₈ClNO₃S
• Molecular Weight: 363.865
• Mol file: 958851-00-8.mol

Synonyms:4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-methylsulfonyloxybutane

Chemical Property of 4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-methylsulfonyloxybutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-methylsulfonyloxybutane

There total 2 articles about 4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-methylsulfonyloxybutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + 4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-butanol → 4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-methylsulfonyloxybutane (958851-00-8)

Guidance literature:

With triethylamine; In toluene; at 0 ℃; for 0.0833333h;

Reference yield:

3-(3-bromophenyl)-4-(4-chlorophenyl)butan-2-one (848310-98-5) → 4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-methylsulfonyloxybutane (958851-00-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: L-Selectride / tetrahydrofuran / -60 - 20 °C

1.2: 13 h / 0 - 20 °C

2.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis(diphenylphosphino)ferrocene / water; N,N-dimethyl-formamide / 7 h / 20 - 115 °C

2.2: 1 h

3.1: triethylamine / toluene / 0.08 h / 0 °C

With L-Selectride; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis(diphenylphosphino)ferrocene; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-methylsulfonyloxybutane (958851-00-8) → 4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-azidobutane (958851-01-9)

Guidance literature:

With sodium azide; In DMF (N,N-dimethyl-formamide); at 70 ℃; for 1h;

upstream raw materials:

methanesulfonyl chloride

3-(3-bromophenyl)-4-(4-chlorophenyl)butan-2-one

Downstream raw materials:

4-(4-chlorophenyl)-3-(3-cyanophenyl)-2-azidobutane

N-(1S,2S)-[2-(3-cyanophenyl)-3-(4-chlorophenyl)-1-methylpropyl]amine hydrochloride

N-(1S,2S)-[2-(3-cyanophenyl)-3-(4-chlorophenyl)-1-methylpropyl]amine