methyl 7-(3-fluorophenyl)-6-(methyloxy)-3-oxo-3,4-dihydro-5-quinoxalinecarboxylate

Base Information

Chemical Name:methyl 7-(3-fluorophenyl)-6-(methyloxy)-3-oxo-3,4-dihydro-5-quinoxalinecarboxylate
CAS No.:1160685-71-1
Molecular Formula:C₁₇H₁₃FN₂O₄
Molecular Weight:328.3
Hs Code.:

Synonyms:methyl 7-(3-fluorophenyl)-6-(methyloxy)-3-oxo-3,4-dihydro-5-quinoxalinecarboxylate

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Chemical Property of methyl 7-(3-fluorophenyl)-6-(methyloxy)-3-oxo-3,4-dihydro-5-quinoxalinecarboxylate

Chemical Property:

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Technology Process of methyl 7-(3-fluorophenyl)-6-(methyloxy)-3-oxo-3,4-dihydro-5-quinoxalinecarboxylate

There total 7 articles about methyl 7-(3-fluorophenyl)-6-(methyloxy)-3-oxo-3,4-dihydro-5-quinoxalinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.1%

: 1160685-70-0
methyl 7-bromo-6-(methyloxy)-3-oxo-3,4-dihydro-5-quinoxalinecarboxylate

: 768-35-4
3-fluorophenylboronic acid

: 1160685-71-1
methyl 7-(3-fluorophenyl)-6-(methyloxy)-3-oxo-3,4-dihydro-5-quinoxalinecarboxylate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 110 ℃; for 3h; Inert atmosphere;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160685-71-1
methyl 7-(3-fluorophenyl)-6-(methyloxy)-3-oxo-3,4-dihydro-5-quinoxalinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid; nitric acid / 0 - 20 °C

2: ammonium hydroxide / ethanol; water / 20 °C

3: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4: bromine / dichloromethane / 0.5 h / 20 °C

5: tin(II) chloride dihdyrate; ethanol / 2 h / Reflux

6: methanol; dichloromethane; toluene / 2 h / 80 °C

7: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

With ammonium hydroxide; tin(II) chloride dihdyrate; ethanol; sulfuric acid; bromine; nitric acid; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; mineral oil;

Reference yield:

: 346691-23-4
methyl 2-amino-6-fluoro-3-nitrobenzoate

: 1160685-71-1
methyl 7-(3-fluorophenyl)-6-(methyloxy)-3-oxo-3,4-dihydro-5-quinoxalinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2: bromine / dichloromethane / 0.5 h / 20 °C

3: tin(II) chloride dihdyrate; ethanol / 2 h / Reflux

4: methanol; dichloromethane; toluene / 2 h / 80 °C

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

With tin(II) chloride dihdyrate; ethanol; bromine; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; toluene; mineral oil;