Technology Process of N-BOC-7-BENZYL-2,7-DIAZASPIRO[3.5]NONANE
There total 5 articles about N-BOC-7-BENZYL-2,7-DIAZASPIRO[3.5]NONANE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-Benzyl-2,7-diaza-spiro[3.5]nonan-1-one;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
Inert atmosphere;
Reflux;
di-tert-butyl dicarbonate;
In
dichloromethane;
for 60h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen / methanol / 50 °C / 2068.65 Torr
2.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux
2.2: 60 h
With
lithium aluminium tetrahydride; hydrogen;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 5 °C / Inert atmosphere
2.2: 1 h / 5 °C
3.1: hydrogen / methanol / 50 °C / 2068.65 Torr
4.1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux
4.2: 60 h
With
lithium aluminium tetrahydride; hydrogen; potassium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
