oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester

Base Information

Chemical Name:oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester
CAS No.:869494-64-4
Molecular Formula:C₄₁H₃₇F₁₃O₆
Molecular Weight:872.72
Hs Code.:

Synonyms:oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester

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Chemical Property of oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester

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Technology Process of oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester

There total 3 articles about oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 869494-63-3
11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-ol

: 5781-53-3
monomethyl oxalyl chloride

: 869494-64-4
oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -60 - 20 ℃; for 1h;
DOI:10.1021/jo051424k

Reference yield:

: 355-43-1
n-perfluorohexyl iodide

: 869494-64-4
oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: MeMgBr / diethyl ether / 0.5 h / -60 °C

1.2: 51 percent / diethyl ether; tetrahydrofuran / 2 h / -60 °C

2.1: 41 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -60 - 20 °C

With n-butyllithium; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/jo051424k

Reference yield:

: 89155-71-5
(8S,9S,13S,14S,17S)-3,17-bis(benzyloxy)-13-methyl-6,7,8,9,12,13,14,15,16,17-decahydro-11H-cyclopenta[a]phenanthren-11-one

: 869494-64-4
oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: MeMgBr / diethyl ether / 0.5 h / -60 °C

1.2: 51 percent / diethyl ether; tetrahydrofuran / 2 h / -60 °C

2.1: 41 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -60 - 20 °C

With n-butyllithium; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/jo051424k