11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-ol

Base Information

• Chemical Name: 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-ol
• CAS No.: 869494-63-3
• Molecular Formula: C₃₈H₃₅F₁₃O₃
• Molecular Weight: 786.673
• Mol file: 869494-63-3.mol

Synonyms:11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-ol

Chemical Property of 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-ol

There total 1 articles about 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

n-perfluorohexyl iodide (355-43-1) + (8S,9S,13S,14S,17S)-3,17-bis(benzyloxy)-13-methyl-6,7,8,9,12,13,14,15,16,17-decahydro-11H-cyclopenta[a]phenanthren-11-one (89155-71-5) → 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-ol (869494-63-3)

Guidance literature:

n-perfluorohexyl iodide; With methylmagnesium bromide; In diethyl ether; at -60 ℃; for 0.5h;

(8S,9S,13S,14S,17S)-3,17-bis(benzyloxy)-13-methyl-6,7,8,9,12,13,14,15,16,17-decahydro-11H-cyclopenta[a]phenanthren-11-one; In tetrahydrofuran; diethyl ether; at -60 ℃; for 2h;

DOI:10.1021/jo051424k

Reference yield: 41.0%

11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-ol (869494-63-3) + monomethyl oxalyl chloride (5781-53-3) → oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester (869494-64-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -60 - 20 ℃; for 1h;

DOI:10.1021/jo051424k

Reference yield:

11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-ol (869494-63-3) → 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene (869494-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -60 - 20 °C

2: Bu₃SnH; AIBN / toluene / 14 h / Heating

With n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; hexane; toluene;

DOI:10.1021/jo051424k

upstream raw materials:

n-perfluorohexyl iodide

(8S,9S,13S,14S,17S)-3,17-bis(benzyloxy)-13-methyl-6,7,8,9,12,13,14,15,16,17-decahydro-11H-cyclopenta[a]phenanthren-11-one

Downstream raw materials:

oxalic acid 11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-yl ester methyl ester

11α-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene

11β-tridecafluorohexyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene