Methyl 4,5-diphenyl-2-oxazolecarboxylate

Base Information

Chemical Name:Methyl 4,5-diphenyl-2-oxazolecarboxylate
CAS No.:26820-92-8
Molecular Formula:C₁₇H₁₃NO₃
Molecular Weight:279.295
Hs Code.:
DSSTox Substance ID:DTXSID801277169

Synonyms:Methyl 4,5-diphenyl-2-oxazolecarboxylate;SCHEMBL9428384;DTXSID801277169;26820-92-8

Suppliers and Price of Methyl 4,5-diphenyl-2-oxazolecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 4,5-diphenyl-2-oxazolecarboxylate

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:279.08954328
Heavy Atom Count:21
Complexity:348

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=NC(=C(O1)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Methyl 4,5-diphenyl-2-oxazolecarboxylate

There total 3 articles about Methyl 4,5-diphenyl-2-oxazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 451-40-1
phenyl benzyl ketone

: 17640-15-2
methyl cyanoformate

: 26820-92-8
methyl 4,5-diphenyl-2-oxazolecarboxylate

Guidance literature:: With potassium peroxymonosulfate sulfate; trifluorormethanesulfonic acid; iodine; at 70 ℃; for 6h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c00235

Reference yield:

: 5781-53-3
monomethyl oxalyl chloride

: 119-53-9,579-44-2
2-hydroxy-2-phenylacetophenone

: 26820-92-8
methyl 4,5-diphenyl-2-oxazolecarboxylate

Guidance literature:: With ammonium acetate; acetic acid; triethylamine; Yield given. Multistep reaction; 1.) THF, 45 min, 2.) THF, reflux, 6 h;
DOI:10.1021/jm00076a018