(2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester

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Chemical Name:(2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester
CAS No.:140660-53-3
Molecular Formula:C₃₅H₅₆N₄O₈
Molecular Weight:660.852
Hs Code.:

(2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester

Synonyms:(2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester

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Chemical Property of (2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester

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Technology Process of (2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester

There total 2 articles about (2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 117611-44-6
Z-Leu-nLeu-OH

: 76684-89-4
loxistatin acid

: 140660-53-3
(2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1021/jm00089a015

Reference yield:

: 88321-09-9
aloxistatin

: 140660-53-3
(2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / ethanol / 5 h / 0 - 20 °C

2: 77 percent / EDCI, DMAP / CH₂Cl₂ / 3 h / 0 - 20 °C

With dmap; potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/jm00089a015