76684-89-4

Usage

InChI:InChI=1/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1

Upstream product

• 84851-37-6 N¹-isoamylleucinamide 
• 66866-44-2 Boc-Leu-O-COO-isoBu 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 107-85-7 1-amino-3-methylbutane 
• 915697-54-0 C₁₇H₂₁NO₅ 
• 915697-61-9 C₁₆H₁₉NO₅ 
• 915697-59-5 C₂₁H₃₀N₂O₄ 
• 915697-62-0 C₂₁H₃₀N₂O₅ 
• 88321-09-9 aloxistatin 
• 84863-67-2 (S)-t-butyl 1-(isopentylamino)-4-methyl-1-oxopentan-2-ylcarbamate 
• 84851-37-6 (S)-1-(isopentylamino)-2-amino-4-methyl-1-oxopentan hydrochloride 

Downstream Products

• 140660-52-2 (2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid 2-chloro-benzyl ester 
• 140660-53-3 (2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxirane-2-carboxylic acid (S)-2-((S)-2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-hexyl ester 
• 140660-60-2 N-<2-<5-(benzyloxy)-1H-indol-3-yl>ethyl> (2S,3S)-3-<<(S)-3-methyl-1-<(3-methylbutyl)carbamoyl>butyl>carbamoyl>-2-oxiranecarboxamide 
• 140660-55-5 5-<3-<2-ethyl>-1H-indolyl> (+)-(2S,3S)-3-<<(S)-3-methyl-1-<(3-methylbutyl)carbamoyl>butyl>carbamoyl>-2-oxiranecarboxylate 
• 140660-56-6 (R)-2-({(2S,3S)-3-[(S)-3-Methyl-1-(3-methyl-butylcarbamoyl)-butylcarbamoyl]-oxiranecarbonyl}-amino)-3-phenyl-propionic acid methyl ester 

Relevant academic research and scientific papers

Design, synthesis, and screen of cathepsin K inhibitors

We synthesized a series of epoxysuccinic acid derivatives and evaluated their in vitro cathepsin K inhibitory activity The screening results show that the potency of compounds 9e, 9d, 9p, 9j and 9k (IC50 ≤ 0.005 μmol/L) were equal to or greater than that of the lead compound 9a. Less hydrophobic compounds showed weaker potency, which can be explained by the hydrophobic nature of the cathepsin K binding pockets.

Stereoselective synthesis of the epoxysuccinyl peptide E-64c

A highly diastereoselective PTC epoxidation is employed in the synthesis of the potent cysteine protease inhibitor E-64c. Georg Thieme Verlag Stuttgart.

Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors

Analogs of the epoxysuccinyl peptide cysteine proteinase inhibitor, EP- 475 (2a), in which the free carboxylate has been replaced by hydroxamic acid, amide, methyl ketone, hydroxyl, and ethyl ester functionalities, have been synthesized. Individual rate c

Ester and amide derivatives of E64c as inhibitors of platelet calpains

Ester and amide derivatives of E64c, (+)-(2S,3S)-3-[[(S)-3-methyl-1-[(3- methylbutyl)carbamoyl]butyl]carbamoyl]-2-oxiranecarboxylic acid, an inhibitor of calpains, were synthesized and tested for ability to inhibit calpain in lysed cells, ability to enter