5'-O-dimethoxytritylthymidin-3'-yl N(3'-tert-butyldimethylsilyl-thymidin-5'-yl)-H-phosphonamidate

Base Information

Chemical Name:5'-O-dimethoxytritylthymidin-3'-yl N(3'-tert-butyldimethylsilyl-thymidin-5'-yl)-H-phosphonamidate
CAS No.:247564-82-5
Molecular Formula:C₄₇H₆₀N₅O₁₂PSi
Molecular Weight:946.079
Hs Code.:

Synonyms:5'-O-dimethoxytritylthymidin-3'-yl N(3'-tert-butyldimethylsilyl-thymidin-5'-yl)-H-phosphonamidate

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Chemical Property of 5'-O-dimethoxytritylthymidin-3'-yl N(3'-tert-butyldimethylsilyl-thymidin-5'-yl)-H-phosphonamidate

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Technology Process of 5'-O-dimethoxytritylthymidin-3'-yl N(3'-tert-butyldimethylsilyl-thymidin-5'-yl)-H-phosphonamidate

There total 2 articles about 5'-O-dimethoxytritylthymidin-3'-yl N(3'-tert-butyldimethylsilyl-thymidin-5'-yl)-H-phosphonamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3868-27-7
triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate

: 247564-82-5
5'-O-dimethoxytritylthymidin-3'-yl N(3'-tert-butyldimethylsilyl-thymidin-5'-yl)-H-phosphonamidate

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl chlorophosphate; pyridine / CH₂Cl₂ / 0.5 h

2: trimethylsilyl chloride; Et₃N / pyridine; CH₂Cl₂ / 0.33 h

With pyridine; chloro-trimethyl-silane; triethylamine; chlorophosphoric acid diphenyl ester; In pyridine; dichloromethane; 1: Condensation / 2: Substitution;
DOI:10.1016/S0040-4020(99)00656-0

Reference yield:

: 180475-92-7
2,4,6-Trichlorophenyl 5'-O-dimethoxytritylthymidin-3'-yl phosphonate

: 130128-70-0
5'-amino-3'-O-(tert-butyldimethylsilyl)-5’-deoxythymidine

: 247564-82-5
5'-O-dimethoxytritylthymidin-3'-yl N(3'-tert-butyldimethylsilyl-thymidin-5'-yl)-H-phosphonamidate

Guidance literature:: With chloro-trimethyl-silane; triethylamine; In pyridine; dichloromethane; for 0.333333h;
DOI:10.1016/S0040-4020(99)00656-0