180475-92-7

Upstream product

• 3868-27-7 triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 88-06-2 2,4,6-Trichlorophenol 
• 50571-26-1 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 130288-81-2 5'-O-dimethoxytrityl-2'-deoxythymidine-3'-H-phosphonate 

Downstream Products

• 307309-80-4 C₄₀H₄₂Cl₃N₂O₉PSi 
• 908248-49-7 C₄₆H₅₃N₄O₁₀PSi 
• 247564-82-5 5'-O-dimethoxytritylthymidin-3'-yl N(3'-tert-butyldimethylsilyl-thymidin-5'-yl)-H-phosphonamidate 
• 104655-85-8 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl N,N-diisopropyl-H-phosphonamidate 
• 157793-53-8 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl N-butylphosphonamidate 

Relevant academic research and scientific papers

Synthesis of nucleoside boranophosphoramidate prodrugs conjugated with amino acids

(Chemical Equation Presented) Nucleoside boranophosphates and nucleoside amino acid phosphoramidates have been shown to be potent antiviral and anticancer agents with the potential to act as nucleoside prodrugs. A combination of these two types of compoun

Model synthesis of nucleoside boranophosphoramidate with amino acid for prodrug purpose

A model synthesis of a nucleoside boranophosphoramidate prodrug with (L)-tryptophan methyl ester was accomplished in a one-pot reaction via an H-phosphonate approach. This new type of compound is expected to possess the potent antiviral and anticancer adv

Aryl H-phosphonates. Part 13. A new, general entry to aryl nucleoside phosphate and aryl nucleoside phosphorothioate diesters

The reaction of nucleoside H-phosphonate monoesters with phenols in the presence of a condensing agent, followed by oxidation of the in-situ-generated aryl nucleoside H-phosphonate diesters with iodine-water or with elemental sulfur, provides a new, 'one-

Aryl H-Phosphonates. 12. Synthetic and 31P NMR Studies on the Preparation of Nucleoside H-Phosphonothioate and Nucleoside H-Phosphonodithioate Monoesters

Transformation of nucleoside H-phosphonate monoesters into the corresponding H-phosphonothioate and H-phosphonodithioate derivatives and possible side-reactions that may accompany this process were studied using 31P NMR spectroscopy. These provided new insight into a possible mechanism involved in this transformation and constituted the basis for development of efficient methods for the preparation of nucleoside H-phosphonothioate and nucleoside H-phosphonodithioate monoesters using readily available H-phosphonate monoesters as starting materials.

Aryl H-phosphonates. 10. Synthesis of nucleoside phosphoramidate and nucleoside phosphoramidothioate analogues via H-phosphonamidate intermediates

Synthesis of a new type of dinucleoside monophosphate analogue with the 3'-5' H-phosphonamidate internucleoside linkage, namely thymidin-3'-yl N(thymidin-5'-yl)-H-phosphonamidate 4, was achieved via the reaction of a suitably protected nucleoside aryl H-p

Aryl H-phosphonates. Part 11. Synthetic and 31P NMR studies on the formation of aryl nucleoside H-phosphonates

The formation of aryl H-phosphonate diesters from the corresponding nucleoside 3′-H-phosphonates and various phenols was investigated in detail using 31P NMR spectroscopy. The major reaction pathways of aryl nucleoside H-phosphonates under diff

Aryl H-phosphonates. 6. Synthetic studies on the preparation of nucleoside N-alkyl-H-phosphonamidates

Various approaches to the synthesis of nucleoside H-phosphonamidates have been investigated. Direct couplings of nucleoside H-phosphonates with amines have been hampered by extensive reactions of the condensing agents with amines. Preactivation of nucleos

Aryl H-phosphonates. Part IV. A new method for internucleotide bond formation based on transesterification of aryl nucleoside H-phosphonate diesters

Under mild reaction conditions nucleoside aryl H-phosphonate diesters undergo fast and efficient transesterification with suitably protected nucleosides, affording dinucleoside (3'-5') H-phosphonate diesters.