2-(4-benzyloxy-benzyl)-N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-malonamide

Base Information

Chemical Name:2-(4-benzyloxy-benzyl)-N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-malonamide
CAS No.:345269-72-9
Molecular Formula:C₃₀H₄₄N₂O₅
Molecular Weight:512.69
Hs Code.:

2-(4-benzyloxy-benzyl)-<i>N</i>,<i>N</i>'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-malonamide

Synonyms:2-(4-benzyloxy-benzyl)-N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-malonamide

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Chemical Property of 2-(4-benzyloxy-benzyl)-N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-malonamide

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Technology Process of 2-(4-benzyloxy-benzyl)-N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-malonamide

There total 7 articles about 2-(4-benzyloxy-benzyl)-N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 112245-13-3
(S)-tert-leucinol

: 2-(4-benzyloxy-benzyl)-2-methyl-propanedioyl dichloride

: 345269-72-9
2-(4-benzyloxy-benzyl)-N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-malonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jo010077l

Reference yield:

: 623-05-2
(4-hydroxyphenyl)methanol

: 345269-72-9
2-(4-benzyloxy-benzyl)-N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-malonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: K₂CO₃

2.1: PBr₃

3.1: LDA / tetrahydrofuran / 1 h / 0 °C

3.2: 86 percent / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: KOH / ethanol; H₂O / 48 h / Heating

5.1: thionyl chloride / toluene / 4 h / Heating

6.1: 90 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

With potassium hydroxide; thionyl chloride; phosphorus tribromide; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jo010077l

Reference yield:

: 836-43-1
4-benzyloxybenzyl alcohol

: 345269-72-9
2-(4-benzyloxy-benzyl)-N,N'-bis-(1-hydroxymethyl-2,2-dimethyl-propyl)-2-methyl-malonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: PBr₃

2.1: LDA / tetrahydrofuran / 1 h / 0 °C

2.2: 86 percent / tetrahydrofuran / 16 h / 0 - 20 °C

3.1: KOH / ethanol; H₂O / 48 h / Heating

4.1: thionyl chloride / toluene / 4 h / Heating

5.1: 90 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

With potassium hydroxide; thionyl chloride; phosphorus tribromide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jo010077l