3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionamide hydrochloride

Base Information

Chemical Name:3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionamide hydrochloride
CAS No.:1433388-75-0
Molecular Formula:C₂₀H₂₃ClFN₃O₂*ClH
Molecular Weight:428.334
Hs Code.:

Synonyms:3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionamide hydrochloride

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Chemical Property of 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionamide hydrochloride

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Technology Process of 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionamide hydrochloride

There total 10 articles about 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433407-55-6
3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid

: 1433388-75-0
3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionamide hydrochloride

Guidance literature:: 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid; With ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 18h;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 1433405-92-5
(R)-1-(4-chloro-2-fluorophenyl)propylamine L-aspartate

: 1433388-75-0
3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Large scale

1.2: 20 °C / Large scale

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 0.75 h

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h

4.1: sodium hydroxide / water; 1,2-dichloro-ethane / pH 12

4.2: 3 h

5.1: water; sodium hydroxide / tetrahydrofuran / 20 °C

6.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h

With hydrogenchloride; n-butyllithium; water; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1433401-71-8
[(R)-1-(4-chloro-2-fluoro-phenyl)-propyl]-carbamic acid tert-butyl ester

: 1433388-75-0
3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 0.75 h

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h

3.1: sodium hydroxide / water; 1,2-dichloro-ethane / pH 12

3.2: 3 h

4.1: water; sodium hydroxide / tetrahydrofuran / 20 °C

5.1: ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h

With hydrogenchloride; n-butyllithium; water; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;