3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid

Base Information

Chemical Name:3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid
CAS No.:1433407-55-6
Molecular Formula:C₂₀H₂₂ClFN₂O₃
Molecular Weight:392.858
Hs Code.:

Synonyms:3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid

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Chemical Property of 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid

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Technology Process of 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid

There total 9 articles about 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433407-47-6
3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid isobutyl ester

: 1433407-55-6
3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1433405-92-5
(R)-1-(4-chloro-2-fluorophenyl)propylamine L-aspartate

: 1433407-55-6
3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Large scale

1.2: 20 °C / Large scale

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 0.75 h

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h

4.1: sodium hydroxide / water; 1,2-dichloro-ethane / pH 12

4.2: 3 h

5.1: water; sodium hydroxide / tetrahydrofuran / 20 °C

With hydrogenchloride; n-butyllithium; water; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 1433401-71-8
[(R)-1-(4-chloro-2-fluoro-phenyl)-propyl]-carbamic acid tert-butyl ester

: 1433407-55-6
3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 0.75 h

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h

3.1: sodium hydroxide / water; 1,2-dichloro-ethane / pH 12

3.2: 3 h

4.1: water; sodium hydroxide / tetrahydrofuran / 20 °C

With hydrogenchloride; n-butyllithium; water; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1,2-dichloro-ethane;