3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid isobutyl ester

Base Information

• Chemical Name: 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid isobutyl ester
• CAS No.: 1433407-47-6
• Molecular Formula: C₂₄H₃₀ClFN₂O₃
• Molecular Weight: 448.965
• Mol file: 1433407-47-6.mol

Synonyms:3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid isobutyl ester

Chemical Property of 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid isobutyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid isobutyl ester

There total 9 articles about 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid isobutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethyl-3-oxopropionic acid isobutyl ester (1433407-39-6) + [3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl]pyridin-3-ylmethanone hydrochloride → 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid isobutyl ester (1433407-47-6)

Guidance literature:

[3-((R)-1-aminopropyl)-6-chloro-2-fluorophenyl]pyridin-3-ylmethanone hydrochloride; With sodium hydroxide; In water; 1,2-dichloro-ethane; pH=12;

2,2-dimethyl-3-oxopropionic acid isobutyl ester; With sodium tris(acetoxy)borohydride; acetic acid; for 3h;

Reference yield:

(R)-1-(4-chloro-2-fluorophenyl)propylamine L-aspartate (1433405-92-5) → 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid isobutyl ester (1433407-47-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Large scale

1.2: 20 °C / Large scale

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 0.75 h

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h

4.1: sodium hydroxide / water; 1,2-dichloro-ethane / pH 12

4.2: 3 h

With hydrogenchloride; n-butyllithium; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

[(R)-1-(4-chloro-2-fluoro-phenyl)-propyl]-carbamic acid tert-butyl ester (1433401-71-8) → 3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid isobutyl ester (1433407-47-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 0.75 h

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h

3.1: sodium hydroxide / water; 1,2-dichloro-ethane / pH 12

3.2: 3 h

With hydrogenchloride; n-butyllithium; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1,2-dichloro-ethane;

upstream raw materials:

[(R)-1-(4-chloro-2-fluoro-phenyl)-propyl]-carbamic acid tert-butyl ester

(R)-1-(4-chloro-2-fluorophenyl)propylamine L-aspartate

isobutyl isobutanoate

(1-isobutoxy-2-methylpropenyloxy)trimethylsilane

Downstream raw materials:

3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionamide hydrochloride

3-{(R)-1-[4-chloro-2-fluoro-3-(pyridine-3-carbonyl)phenyl]propylamino}-2,2-dimethylpropionic acid