(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanamine hydrochloride

Base Information

• Chemical Name: (3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanamine hydrochloride
• CAS No.: 1187947-35-8
• Molecular Formula: C₁₁H₁₃FN₂O₂*ClH
• Molecular Weight: 260.696
• Mol file: 1187947-35-8.mol

Synonyms:(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanamine hydrochloride

Chemical Property of (3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanamine hydrochloride

There total 1 articles about (3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.82%

3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carbonitrile (1187946-87-7) → (3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanamine hydrochloride (1187947-35-8)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 2h; under 3102.97 Torr;

DOI:10.1016/j.bmcl.2009.06.052

Reference yield:

(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanamine hydrochloride (1187947-35-8) + pivaloyl chloride (3282-30-2) → C16H21FN2O3 (1206905-92-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2009.06.052

Reference yield:

(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)methanamine hydrochloride (1187947-35-8) + isopentanoyl chloride (108-12-3) → C16H21FN2O3

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2009.06.052

upstream raw materials:

3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazole-5-carbonitrile

Downstream raw materials:

C₁₆H₂₁FN₂O₃