C₃₃H₄₁F₃O₆

Base Information

• Chemical Name: C₃₃H₄₁F₃O₆
• CAS No.: 1352034-35-5
• Molecular Formula: C₃₃H₄₁F₃O₆
• Molecular Weight: 590.68
• Mol file: 1352034-35-5.mol

Synonyms:C₃₃H₄₁F₃O₆

Chemical Property of C₃₃H₄₁F₃O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₄₁F₃O₆

There total 14 articles about C₃₃H₄₁F₃O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-11,12,14-trimethoxy-9(10->20)-5aH-abeo-abieta-1(10),8,11,13-tetraen-1-ol (1006709-03-0) + (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) → C33H41F3O6 (1352034-35-5)

Guidance literature:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride; With pyridine; In dichloromethane; Inert atmosphere;

(R)-11,12,14-trimethoxy-9(10->20)-5aH-abeo-abieta-1(10),8,11,13-tetraen-1-ol; In dichloromethane; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1016/j.tet.2011.09.072

Reference yield:

3-(1-methylethyl)-1,2,4-trimethoxybenzene (60241-78-3) → C33H41F3O6 (1352034-35-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tert-butyl methyl ether / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 6.5 h / 0 - 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / ethanol / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: phosphorus tribromide / diethyl ether / 0.08 h / 0 °C / Inert atmosphere

4.1: potassium carbonate; potassium iodide / tetrahydrofuran; water / 24 h / 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

5.2: 12 h / 20 °C / Inert atmosphere

6.1: cerium(III) chloride / tetrahydrofuran; diethyl ether / 13 h / 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

7.1: titanium tetrachloride / dichloromethane / 0.83 h / -78 - 20 °C / Inert atmosphere

7.2: 20 °C / Inert atmosphere

8.1: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

9.1: pyridine / dichloromethane / Inert atmosphere

9.2: 72 h / 20 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; n-butyllithium; cerium(III) chloride; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; phosphorus tribromide; titanium tetrachloride; sodium hydride; potassium carbonate; potassium iodide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; 6.1: Grignard reaction;

DOI:10.1016/j.tet.2011.09.072

Reference yield:

2,3,5-trimethoxybenzoic acid (36873-96-8) → C33H41F3O6 (1352034-35-5)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sulfuric acid / 2.5 h / 45 °C / Inert atmosphere

1.2: 8 h / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / diethyl ether / 4 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: phosphorus tribromide / diethyl ether / 0.08 h / 0 °C / Inert atmosphere

4.1: potassium carbonate; potassium iodide / tetrahydrofuran; water / 24 h / 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

5.2: 12 h / 20 °C / Inert atmosphere

6.1: cerium(III) chloride / tetrahydrofuran; diethyl ether / 13 h / 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

7.1: titanium tetrachloride / dichloromethane / 0.83 h / -78 - 20 °C / Inert atmosphere

7.2: 20 °C / Inert atmosphere

8.1: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

9.1: pyridine / dichloromethane / Inert atmosphere

9.2: 72 h / 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; cerium(III) chloride; dimethylsulfide borane complex; sulfuric acid; phosphorus tribromide; titanium tetrachloride; sodium hydride; potassium carbonate; potassium iodide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 6.1: Grignard reaction;

DOI:10.1016/j.tet.2011.09.072

upstream raw materials:

4-(1-methylethyl)-2,3,5-trimethoxybenzaldehyde

(R)-11,12,14-trimethoxy-9(10->20)-5aH-abeo-abieta-1(10),8,11,13-tetraen-1-ol

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

4,4-dimethylcyclohexane-1,3-dione