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Usage

Uses

Used in Pharmaceutical Industry:
2,3,5-triMethoxybenzoic acid is used as an intermediate in the synthesis of various pharmaceutical compounds due to its unique chemical structure and properties. Its anti-inflammatory and antioxidant characteristics make it a valuable component in the development of new drugs for medical applications.
Used in Chemical Industry:
In the chemical industry, 2,3,5-triMethoxybenzoic acid serves as a key building block for the synthesis of a range of organic compounds, contributing to the creation of novel materials and products.
Used in Dietary Supplements:
2,3,5-triMethoxybenzoic acid is used as an ingredient in dietary supplements for its potential health benefits, including its antioxidant properties that may contribute to overall well-being and support a healthy lifestyle.
Used in Pharmaceutical Formulations:
2,3,5-triMethoxybenzoic acid is utilized in the formulation of pharmaceutical formulations, leveraging its anti-inflammatory properties to aid in the treatment of various conditions that may benefit from reduced inflammation.

Upstream product

• 23030-39-9 1-bromo-2,3,5-trimethoxybenzene 
• 124-38-9 carbon dioxide 
• 2179-22-8 2,5-dihydroxy-3-methoxybenzaldehyde 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 128670-46-2 5-amino-2,3 -dimethoxybenzoic acid 
• 72517-25-0 2,3-dimethoxy-5-nitrobenzoic acid 
• 611-68-7 2-methoxy-6-methyl-1,4-benzoquinone 
• 77-78-1 dimethyl sulfate 
• 75510-58-6 2,3,5-trimethoxy-benzonitrile 
• 116530-57-5 5-hydroxy-2,3-dimethoxy-benzoic acid 
• 5556-84-3 2,3,5-trimethoxy-benzaldehyde 
• 186581-53-3 diazomethane 

Downstream Products

• 33580-60-8 2,3,5-trihydroxybenzoic acid 
• 61637-60-3 3,5-dimethoxysalicylic acid 
• 119098-80-5 4,5-dihydro-2-(2,3,5-trimethoxyphenyl)-4,4-dimethyloxazole 
• 153335-58-1 N-(2-Hydroxy-1,1-dimethyl-ethyl)-2,3,5-trimethoxy-benzamide 
• 5273-82-5 (E)-1,2,5-trimethoxy-3-(prop-1-en-1-yl)benzene 
• 113524-10-0 (E)-1-(2,3,5-triacetoxyphenyl)prop-1-ene 
• 113524-08-6 C₁₃H₂₃N₂O₅P 
• 113524-14-4 (E)-1-(2,3,5-triacetoxy-6-chlorophenyl)prop-1-ene 
• 113523-95-8 1-oxo-1-(2,3,5-trimethoxyphenyl)propan-2-ylphosphonic bis(dimethylamide) 
• 113523-98-1 1-hydroxy-1-(2,3,5-trimethoxyphenyl)propan-2-ylphosphonic bis(dimethylamide) 
• 113524-13-3 C₁₃H₂₂ClN₂O₅P 
• 113524-07-5 (E)-1-(2,3,5-tribenzyloxyphenyl)prop-1-ene 
• 113523-99-2 1-hydroxy-1-(2,3,5-tribenzyloxyphenyl)propan-2-ylphosphonic bis(dimethylamide) 
• 113524-05-3 1-hydroxy-1-(2,3,5-tribenzyloxy-6-chlorophenyl)propan-2-ylphosphonic bis(dimethylamide) 

Relevant academic research and scientific papers

Synthesis of polyhydroxylated flavonoids bearing a lipophilic decyl tail as potential therapeutic antioxidants

Antioxidants have potential for the treatment of stroke and neurodegeneration, and chimeric compounds that combine a flavon-3-ol head group related to myricetin and a lipophilic decyl tail are known to protect membranes from oxidative damage at least as well as vitamin E. New flavon-3-ols that are highly hydroxylated in the B ring in ways not found in natural flavon-3-ols and bearing a lipophilic decyl tail have been prepared from trimethoxy-and tetramethoxybenzoic acids accessed by lithiation-carboxylation reactions. Direct enolate acylation was preferred over Baker-Venkataraman rearrangement when there were methoxy groups at both the 2-and the 6-position of the benzoic acid derivatives.

Synthesis of (±)- and (+)-perovskone

A biomimetic synthesis of the triterpene (±)-perovskone was achieved featuring a remarkable polycyclization process in which three rings, four bonds, and five stereocenters were created in a single operation in 82% yield. This convergent synthesis required 16 steps, starting from vanillin, and proceeded in 9% overall yield. A second route to prepare optically active quinone 2 took 15 steps in 36% overall yield and featured a palladium-catalyzed reductive allylic transposition to establish the C-5 chirality stereospecifically. Quinone (-)-2 was converted to (+)-perovskone (1) via a polycyclization cascade, which created four rings, five bonds, and six stereocenters in a single operation in 50% yield.

Ga(IIl)-catalyzed cycloisomerization approach to (±)-icetexone and (±)-epi-icetexone

"Chemical eqation presented" A Ga(III)-catalyzed cycloisomerization reaction provides expedient access to a benzannulated cycloheptadiene bearing a cyano group, which has been applied to the syntheses of several icetexane diterpenoids including icetexone

A concise and efficient synthesis of protected actinoidic acid, the degradation product of vancomycin

Protected actinoidic acid 2, one of the degradation products of vancomycin, has been efficiently synthesized by a convergent route which is amenable to large scale application as well as to asymmetric synthesis.

THE SYNTHESIS OF DESERTORIN C, A BICOUMARIN FROM THE FUNGUS EMERICELLA DESERTORUM

The structure of desertorin C, a metabolite of the mould Emericella desertorum, is confirmed as 4,4',7,7'-tetramethoxy-5,5'-dimethyl-6,8'-bicoumarin (6), by its synthesis in racemic form.The key step involved the construction of the unsymmetrical biphenyl