(E)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine

Base Information

Chemical Name:(E)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine
CAS No.:376646-49-0
Molecular Formula:C₁₇H₁₅F₂N₅O
Molecular Weight:343.336
Hs Code.:

Synonyms:(E)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine

Chemical Property:

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Technology Process of (E)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine

There total 3 articles about (E)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.2%

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 381221-86-9
(E,Z)-2-benzyloxymethyl-1-bromo-1-bromomethyl-3,3-difluorocyclopropane

: 376646-48-9
(Z)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine

: 376646-49-0
(E)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine

: 9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}adenine

Guidance literature:: adenine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

(E,Z)-2-benzyloxymethyl-1-bromo-1-bromomethyl-3,3-difluorocyclopropane; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Further stages.;
DOI:10.1021/jm010191w

Reference yield:

: 196495-45-1
2-benzyloxymethyl-3,3-difluoro-1-methylenecyclopropane

: 376646-49-0
(E)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95.1 percent / pyridine hydrobromide perbromide / CH₂Cl₂ / 16 h / 20 °C

2.1: NaH / dimethylformamide / 4 h / 20 °C

2.2: 21.4 percent / dimethylformamide / 16 h / 20 °C

With pyridinium hydrobromide perbromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010191w

Reference yield:

: C₁₈H₁₇F₂NO₄Se

: 376646-49-0
(E)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 48 h / 80 °C

2.1: 95.1 percent / pyridine hydrobromide perbromide / CH₂Cl₂ / 16 h / 20 °C

3.1: NaH / dimethylformamide / 4 h / 20 °C

3.2: 21.4 percent / dimethylformamide / 16 h / 20 °C

With pyridinium hydrobromide perbromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm010191w