196495-45-1

Upstream product

• 381221-85-8 1-(3-Benzyloxymethyl-2,2-difluoro-cyclopropylmethylselanyl)-2-nitro-benzene 
• 128741-83-3 (cis)-1-benzyloxy-4-(tert-butyldimethyl)silyloxy-2-butene 

Downstream Products

• 381221-86-9 (E,Z)-2-benzyloxymethyl-1-bromo-1-bromomethyl-3,3-difluorocyclopropane 
• 376646-48-9 (Z)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine 
• 376646-49-0 (E)-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}adenine 
• 381221-89-2 (Z)-2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}-6-chloropurine 
• 381221-88-1 (E)-2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropylidene]methyl}-6-chloropurine 
• 381221-90-5 2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine 

Relevant academic research and scientific papers

Methylene-gem-difluorocyclopropane analogues of nucleosides: Synthesis, cyclopropene-methylenecyclopropane rearrangement, and biological activity

Alkylation-elimination of adenine and 2-amino-6-chloropurine with gem-difluorocyclopropane dibromide 10 gave E- and Z-methylene-gem-difluorocyclopropane 11a, 11b, 12a, and 12b and gem-difluorocyclopropenes 13a and 13b. Debenzylation of intermediates 11a,

Preparation of methylene-gem-difluorocyclopropanes and its reactivity as Michael Acceptor

Preparation of methylene-gem-difluorocyclopropanes 3 was achieved through the selenoxide elimination reaction derived from gem- difluorocyclopropylmethanols 1, while this method can not be applied to non- fluorinated cyclopropylmethanols. The methylene-gem-difluorocyclopropane 3 showed a high reactivity as a Michael acceptor in the reaction with thiol or amine.