6-Fluoro-2-methylindanone

Base Information

• Chemical Name: 6-Fluoro-2-methylindanone
• CAS No.: 37794-19-7
• Molecular Formula: C10H9FO
• Molecular Weight: 164.179
• Hs Code.: 2914700090
• Mol file: 37794-19-7.mol

Synonyms:1-Indanone,6-fluoro-2-methyl-;6-Fluoro-2-methyl-1-indanone;6-Fluoro-2-methylindanone;6-Fluor-2-methyl-2,3-dihydro-1H-inden-1-on;6-Fluoro-2-methyl-1-indanone;6-Fluor-2-methylindan-1-on;

Chemical Property of 6-Fluoro-2-methylindanone

Chemical Property:

• Vapor Pressure: 0.037mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 240.9 °C at 760 mmHg
• Flash Point: 95.2 °C
• PSA: 17.07000
• Density: 1.179 g/cm₃
• LogP: 2.20060
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: 307.4mg/L at 25℃

Purity/Quality:

99% ^*data from raw suppliers

6-fluoro-2-methyl-2,3-dihydroinden-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Fluoro-2-methylindanone

There total 14 articles about 6-Fluoro-2-methylindanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

C10H10ClFO → 6-fluoro-2-methylindanone (37794-19-7)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 - 10 ℃; for 3h;

Reference yield: 75.0%

2-allyl-5-fluorobenzaldehyde (893620-41-2) → 6-fluoro-2-methylindanone (37794-19-7)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 1,3-di-tert-butylimidazol-2-ylidene; In 1,3,5-trimethyl-benzene; at 130 ℃; for 5h; Inert atmosphere;

DOI:10.1002/anie.201206186

Reference yield:

silica-gel + ether-petroleum ether + 3-(4-fluorophenyl)-2-methylpropanoic acid (22138-73-4) → 6-fluoro-2-methylindanone (37794-19-7)

Guidance literature:

With PPA; In water;

upstream raw materials:

3-(4-fluorophenyl)-2-methylpropanoic acid

(3-fluorophenyl)isopropenylketone

sodium carbonate

2-bromo-5-fluorobenzaldehyde

Downstream raw materials:

5-fluoro-2-methyl-1H-indene-3-acetic acid

5-fluoro-2-methyl-1-(4-methylsulfanylbenzylidene)-3-indenylacetic acid

Sulindac

sulindac sulfide

Refernces

• 1、 -. "METHODS AND COMPOSITIONS RELATED TO A RETINOID RECEPTOR-SELECTIVE PATHWAY". Paragraph 0156; 0157. . Retrieved 2015/11/09.
• 2、 Hoshimoto, Yoichi,Hayashi, Yukari,Suzuki, Haruka,Ohashi, Masato,Ogoshi, Sensuke. "Synthesis of five- and six-membered benzocyclic ketones through intramolecular alkene hydroacylation catalyzed by Nickel(0)/N-Heterocyclic Carbenes". . p. 10812 - 10815. Retrieved 2013/01/15.