Technology Process of 2-(3-benzyloxy-4,5-dimethoxy-phenyl)-N-(1-phenyl-ethyl)-acetamide
There total 9 articles about 2-(3-benzyloxy-4,5-dimethoxy-phenyl)-N-(1-phenyl-ethyl)-acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
dichloromethane; water;
at 20 ℃;
for 1h;
DOI:10.1021/ol0261635
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: imidazole / dimethylformamide / 12 h / 20 °C
2.1: n-butyllithium / 1 h / -78 °C
2.2: trimethyl borate / 12 h / -78 - 20 °C
2.3: 78 percent / hydrogen peroxide / 12 h / 20 °C
3.1: 75 percent / potassium carbonate / acetone / 12 h / Heating
4.1: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / 0 °C
5.1: SOCl2 / benzene / 12 h / 20 °C
5.2: dimethylsulfoxide; benzene / 20 °C
6.1: 98 percent / sodium hydroxide / ethanol / 20 h / Heating
7.1: oxalyl chloride / benzene / 2 h / 20 °C
8.1: sodium hydroxide / H2O; CH2Cl2 / 1 h / 20 °C
With
1H-imidazole; sodium hydroxide; n-butyllithium; thionyl chloride; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium carbonate;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
8.1: Schotten-Baumann reaction;
DOI:10.1021/ol0261635
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium borohydride / tetrahydrofuran; methanol / 2 h
2.1: imidazole / dimethylformamide / 12 h / 20 °C
3.1: n-butyllithium / 1 h / -78 °C
3.2: trimethyl borate / 12 h / -78 - 20 °C
3.3: 78 percent / hydrogen peroxide / 12 h / 20 °C
4.1: 75 percent / potassium carbonate / acetone / 12 h / Heating
5.1: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6.1: SOCl2 / benzene / 12 h / 20 °C
6.2: dimethylsulfoxide; benzene / 20 °C
7.1: 98 percent / sodium hydroxide / ethanol / 20 h / Heating
8.1: oxalyl chloride / benzene / 2 h / 20 °C
9.1: sodium hydroxide / H2O; CH2Cl2 / 1 h / 20 °C
With
1H-imidazole; sodium hydroxide; sodium tetrahydroborate; n-butyllithium; thionyl chloride; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium carbonate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
9.1: Schotten-Baumann reaction;
DOI:10.1021/ol0261635
