tert-butyl 3-((3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Base Information

Chemical Name:tert-butyl 3-((3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate
CAS No.:1373278-86-4
Molecular Formula:C₂₅H₂₅FN₂O₄
Molecular Weight:436.483
Hs Code.:

Synonyms:tert-butyl 3-((3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Suppliers and Price of tert-butyl 3-((3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 3-((3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3-((3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

There total 5 articles about tert-butyl 3-((3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373278-85-3
methyl 2-((3-(tert-butoxycarbonyl)cyclobutyl)methyl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate

: 1373278-86-4
tert-butyl 3-((3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Guidance literature:: With lithium diisobutyl-tert-butoxyaluminum hydride; In tetrahydrofuran; at 0 ℃; for 3h;

Reference yield:

: 1195-45-5
para-fluorophenyl isocyanate

: 1373278-86-4
tert-butyl 3-((3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / 0 - 60 °C / Inert atmosphere

3.2: 12 h / 60 °C / Inert atmosphere

4.1: lithium diisobutyl-tert-butoxyaluminum hydride / tetrahydrofuran / 3 h / 0 °C

With lithium diisobutyl-tert-butoxyaluminum hydride; N,N-dimethyl-aniline; triethylamine; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 5372-81-6
dimethyl aminoterephthalate

: 1373278-86-4
tert-butyl 3-((3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / 0 - 60 °C / Inert atmosphere

3.2: 12 h / 60 °C / Inert atmosphere

4.1: lithium diisobutyl-tert-butoxyaluminum hydride / tetrahydrofuran / 3 h / 0 °C

With lithium diisobutyl-tert-butoxyaluminum hydride; N,N-dimethyl-aniline; triethylamine; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane;