(1S,2S,2aS,3aR,5R,7aS)-1,2-diphenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol

Base Information

Chemical Name:(1S,2S,2aS,3aR,5R,7aS)-1,2-diphenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol
CAS No.:848033-91-0
Molecular Formula:C₂₅H₃₁NO₂
Molecular Weight:377.527
Hs Code.:

Synonyms:(1S,2S,2aS,3aR,5R,7aS)-1,2-diphenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol

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Chemical Property of (1S,2S,2aS,3aR,5R,7aS)-1,2-diphenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol

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Technology Process of (1S,2S,2aS,3aR,5R,7aS)-1,2-diphenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol

There total 1 articles about (1S,2S,2aS,3aR,5R,7aS)-1,2-diphenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 115156-57-5
(2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine

: N-benzyl-N-[1-(2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-formamide

: 848033-91-0
(1S,2S,2aS,3aR,5R,7aS)-1,2-diphenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol

Guidance literature:: In acetonitrile; at 25 ℃; for 4h; Irradiation;
DOI:10.1021/jo0481497

Reference yield:

: 848033-91-0
(1S,2S,2aS,3aR,5R,7aS)-1,2-diphenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol

: 100-39-0
benzyl bromide

: (1S,2S,3aS,6R,7aR,8aS)-1-Benzyloxy-3,3,6-trimethyl-1,2-diphenyl-octahydro-8-oxa-2a-aza-cyclobuta[b]naphthalene

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 90h;
DOI:10.1021/jo0481497

Reference yield:

: 848033-91-0
(1S,2S,2aS,3aR,5R,7aS)-1,2-diphenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol

: 1025953-40-5
(2S,5R)-2-[1-((2S,3R)-3-Benzyloxy-2,3-diphenyl-azetidin-1-yl)-1-methyl-ethyl]-5-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 90 h / 20 °C

2: LiAlH₄; AlCl₃ / tetrahydrofuran / 3 h / Heating

3: pyridinium chlrochromate; molecular sieves 3 Angstroem / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; aluminium trichloride; 3 A molecular sieve; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0481497