6-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-hexanoic acid methyl ester

Base Information

• Chemical Name: 6-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-hexanoic acid methyl ester
• CAS No.: 209608-43-5
• Molecular Formula: C₂₀H₂₁BrN₂O₅S
• Molecular Weight: 481.367

Synonyms:6-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-hexanoic acid methyl ester

Chemical Property of 6-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-hexanoic acid methyl ester

Chemical Property:

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Technology Process of 6-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-hexanoic acid methyl ester

There total 4 articles about 6-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Methylpimeloyl chloride (35444-47-4) + [3-(4-bromo-2-nitro)phenylsulfanyl]phenylamine (188059-02-1) → 6-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-hexanoic acid methyl ester (209608-43-5)

Guidance literature:

With TEA; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1016/S0960-894X(98)00180-2

Reference yield:

7-methoxy-7-oxoheptanoic acid (20291-40-1) → 6-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-hexanoic acid methyl ester (209608-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SOCl₂ / CH₂Cl₂ / 2 h / Heating

2: 83 percent / TEA / CH₂Cl₂ / 12 h / Ambient temperature

With thionyl chloride; TEA; In dichloromethane;

DOI:10.1016/S0960-894X(98)00180-2

Reference yield:

1,4-dibromo-2-nitrobenzene (3460-18-2) → 6-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-hexanoic acid methyl ester (209608-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / AcONa / ethanol / 36 h / Heating

2: 83 percent / TEA / CH₂Cl₂ / 12 h / Ambient temperature

With TEA; sodium acetate; In ethanol; dichloromethane;

DOI:10.1016/S0960-894X(98)00180-2

upstream raw materials:

Methylpimeloyl chloride

[3-(4-bromo-2-nitro)phenylsulfanyl]phenylamine

7-methoxy-7-oxoheptanoic acid

1,4-dibromo-2-nitrobenzene

Downstream raw materials:

6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester

6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid

6-[3-(2-Amino-4-bromo-phenylsulfanyl)-phenylcarbamoyl]-hexanoic acid methyl ester

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