(2R)-2-<3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2,3-dihydro-2-oxo-1H-imidazol-1-yl>propanoic acid

Base Information

Chemical Name:(2R)-2-<3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2,3-dihydro-2-oxo-1H-imidazol-1-yl>propanoic acid
CAS No.:174563-13-4
Molecular Formula:C₁₅H₁₄F₄N₂O₄
Molecular Weight:362.281
Hs Code.:

Synonyms:(2R)-2-<3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2,3-dihydro-2-oxo-1H-imidazol-1-yl>propanoic acid

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Chemical Property of (2R)-2-<3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2,3-dihydro-2-oxo-1H-imidazol-1-yl>propanoic acid

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Technology Process of (2R)-2-<3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2,3-dihydro-2-oxo-1H-imidazol-1-yl>propanoic acid

There total 1 articles about (2R)-2-<3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2,3-dihydro-2-oxo-1H-imidazol-1-yl>propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 174563-12-3
benzyl (2R)-2-<3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2,3-dihydro-2-oxo-1H-imidazol-1-yl>propanoate

: 174563-13-4
(2R)-2-<3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2,3-dihydro-2-oxo-1H-imidazol-1-yl>propanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 760 Torr; Ambient temperature;
DOI:10.1248/cpb.47.360

Reference yield:

: 79-37-8
oxalyl dichloride

: 174563-13-4
(2R)-2-<3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2,3-dihydro-2-oxo-1H-imidazol-1-yl>propanoic acid

: 174563-14-5
(2R)-2-[3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2,3-dihydro-2-oxo-1H-imidazol-1-yl]propanoyl chloride

Guidance literature:: In N-methyl-acetamide; dichloromethane;

Reference yield:

: 174563-13-4
(2R)-2-<3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2,3-dihydro-2-oxo-1H-imidazol-1-yl>propanoic acid

: 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2-imidazolidinone

Guidance literature:: Multi-step reaction with 7 steps

1: (COCl)2, DMF / CH₂Cl₂ / 2 h / Ambient temperature

2: AlCl₃ / CH₂Cl₂ / 8 h / Heating

3: 1.) Mg, MeI / 1.) THF, from 45 deg C to 50 deg C, 3 h, 2.) THF, 0 deg C, 20 min

4: 78 percent / 30 percent aq. H₂O₂, NaHCO₃ / methanol; tetrahydrofuran / 1.5 h / 70 - 80 °C

5: 91 percent / Et₃N / ethyl acetate / 0.5 h / 0 °C

6: 47 percent / K₂CO₃ / dimethylformamide / 5 h / 90 °C

7: H₂, AcOH / 10 percent Pd/C / 3 h / 50 °C / 760 Torr

With aluminium trichloride; oxalyl dichloride; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; potassium carbonate; magnesium; acetic acid; triethylamine; N,N-dimethyl-formamide; methyl iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.360