(Z)-3-acetyl-1-(4-methoxyphenyl)-8-(2-(tritylamino)thiazol-4-yl)-2,6-dioxa-3,7-diazanon-7-en-9-oic acid

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Chemical Name:(Z)-3-acetyl-1-(4-methoxyphenyl)-8-(2-(tritylamino)thiazol-4-yl)-2,6-dioxa-3,7-diazanon-7-en-9-oic acid
CAS No.:941286-37-9
Molecular Formula:C₃₆H₃₄N₄O₆S
Molecular Weight:650.755
Hs Code.:

Synonyms:(Z)-3-acetyl-1-(4-methoxyphenyl)-8-(2-(tritylamino)thiazol-4-yl)-2,6-dioxa-3,7-diazanon-7-en-9-oic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-3-acetyl-1-(4-methoxyphenyl)-8-(2-(tritylamino)thiazol-4-yl)-2,6-dioxa-3,7-diazanon-7-en-9-oic acid

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Technology Process of (Z)-3-acetyl-1-(4-methoxyphenyl)-8-(2-(tritylamino)thiazol-4-yl)-2,6-dioxa-3,7-diazanon-7-en-9-oic acid

There total 8 articles about (Z)-3-acetyl-1-(4-methoxyphenyl)-8-(2-(tritylamino)thiazol-4-yl)-2,6-dioxa-3,7-diazanon-7-en-9-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 68363-44-0
2-oxo-2-(2-(tritylamino)thiazol-4-yl)acetic acid

: 182068-59-3
N-(2-Aminooxy-ethyl)-N-(4-methoxy-benzyloxy)-acetamide

: 941286-37-9
(Z)-3-acetyl-1-(4-methoxyphenyl)-8-(2-(tritylamino)thiazol-4-yl)-2,6-dioxa-3,7-diazanon-7-en-9-oic acid

Guidance literature:: In ethanol; chloroform; for 10h; Ambient temperature;
DOI:10.1016/0960-894X(96)00381-2

Reference yield:

: 2014-61-1
N-(4-methoxybenzyloxy)phthalimide

: 941286-37-9
(Z)-3-acetyl-1-(4-methoxyphenyl)-8-(2-(tritylamino)thiazol-4-yl)-2,6-dioxa-3,7-diazanon-7-en-9-oic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1.)H₂NNH₂*H₂O, 2.) HCl / 1.) MeOH, room temperature, 10 h, 2.) MeOH, room temperature, 1 h

2: 95 percent / Et₃N / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

3: 52 percent / NaH / dimethylformamide / 15 h / 0 - 10 °C

4: 85 percent / HCl / ethyl acetate / 10 h / 0 deg C - room temperature

5: 98 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 deg C - room temperature

6: 100 percent / H₂NNH₂*H₂O / methanol / 14 h / Ambient temperature

7: 78 percent / ethanol; CHCl₃ / 10 h / Ambient temperature

With hydrogenchloride; sodium hydride; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00381-2

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 941286-37-9
(Z)-3-acetyl-1-(4-methoxyphenyl)-8-(2-(tritylamino)thiazol-4-yl)-2,6-dioxa-3,7-diazanon-7-en-9-oic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / K₂CO₃ / dimethylsulfoxide / 3 h / Ambient temperature

2: 1.)H₂NNH₂*H₂O, 2.) HCl / 1.) MeOH, room temperature, 10 h, 2.) MeOH, room temperature, 1 h

3: 95 percent / Et₃N / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

4: 52 percent / NaH / dimethylformamide / 15 h / 0 - 10 °C

5: 85 percent / HCl / ethyl acetate / 10 h / 0 deg C - room temperature

6: 98 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 deg C - room temperature

7: 100 percent / H₂NNH₂*H₂O / methanol / 14 h / Ambient temperature

8: 78 percent / ethanol; CHCl₃ / 10 h / Ambient temperature

With hydrogenchloride; sodium hydride; potassium carbonate; hydrazine hydrate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00381-2