Sodium methylparaben

Base Information

• Chemical Name: Sodium methylparaben
• CAS No.: 5026-62-0
• Molecular Formula: C8H7NaO3
• Molecular Weight: 174.132
• Hs Code.: 29182930
• Mol file: 5026-62-0.mol

Synonyms:Benzoicacid, 4-hydroxy-, methyl ester, sodium salt (9CI);Sodium, (p-carboxyphenoxy)-, methyl ester(7CI);Bonomold OMNa;Methyl4-hydroxybenzoate sodium salt;Methylparaben sodium;Sodium 4-(methoxycarbonyl)phenoxide;Sodium methylp-hydroxybenzoate;Sodium methylparaben;Sodium p-methoxycarbonylphenoxide;

Chemical Property of Sodium methylparaben

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 0.00555mmHg at 25°C
• Melting Point: >125 °C
• Boiling Point: 265.5 °C at 760 mmHg
• PKA: 8.4[at 20 ℃]
• Flash Point: 116.4 °C
• PSA: 49.36000
• Density: 1.42 g/cm3 (20 °C)
• LogP: 1.61700
• Storage Temp.: Store at +15°C to +25°C.
• Solubility.: Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
• Water Solubility.: 418g/L at 20℃

Purity/Quality:

99%, ^*data from raw suppliers

MethylparabenSodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pharmaceutic aid. Methyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like propyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate. The sodium salt provides improved solubility in water compared to standard methyl 4-hydroxybenzoate.

Technology Process of Sodium methylparaben

There total 2 articles about Sodium methylparaben which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → sodium methylparaben (5026-62-0)

Guidance literature:

With sodium hydroxide; In methanol; Inert atmosphere;

DOI:10.1002/chem.200800229

Reference yield:

4-(N-phenyl-benzimidoyloxy)-benzoic acid methyl ester (73823-12-8) + sodium methylate (124-41-4) → E-[2-methoxy-1-phenyl-methylene]-phenylamine (6780-39-8) + sodium methylparaben (5026-62-0)

Guidance literature:

In methanol; at 29.9 ℃; Mechanism; var. base concentrations;

Reference yield: 98.0%

4-[4'-(1-methoxy carbonyl-1-methylethyl)-phenyl]-1,2-epoxybutane (141969-79-1) + sodium methylparaben (5026-62-0) + methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 4-{4-[4'-(methoxy carbonyl-1-methylethyl)phenyl]-2-hydroxybutoxy}-benzoic acid methyl ester

Guidance literature:

In N,N-dimethyl-formamide;

upstream raw materials:

4-(N-phenyl-benzimidoyloxy)-benzoic acid methyl ester

sodium methylate

methyl 4-hydroxylbenzoate

Downstream raw materials:

C₁₇H₁₄O₆S

trans-2-(p-carbomethoxyphenoxy)-6-carbethoxytetrahydropyran

Indole-1-carboxylic acid 4-methoxycarbonyl-phenyl ester

3,4-dihydroxybenzoic acid methyl ester

Refernces

• 1、 Company, Anna,Palavicini, Sara,Garcia-Bosch, Isaac,Mas-Ballesteì?, Ruben,Que Jr., Lawrence,Rybak-Akimova, Elena V.,Casella, Luigi,Ribas, Xavi,Costas, Miquel. "Tyrosinase-like reactivity in a CuIII2(??-O) 2 species". supporting information; experimental part. p. 3535 - 3538. Retrieved 2009/05/07.
• 2、 Rowe, Jeffrey E.. "Mechanisms of Nucleophilic Attack at Carbon-Nitrogen Double Bonds. The Reaction of Aryl N-Arylbenzimidates with Methoxide Ion". . p. 1259 - 1262. Retrieved 2007/10/02.