ethynylsulfanylmethylbenzene

Base Information

• Chemical Name: ethynylsulfanylmethylbenzene
• CAS No.: 18212-32-3
• Molecular Formula: C₉H₈S
• Molecular Weight: 148.229
• Mol file: 18212-32-3.mol

Synonyms:ethynylsulfanylmethylbenzene

Chemical Property of ethynylsulfanylmethylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethynylsulfanylmethylbenzene

There total 10 articles about ethynylsulfanylmethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl trimethylsilylethynyl sulfide (105066-18-0) → ethynylsulfanylmethylbenzene (18212-32-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; at 20 ℃; for 72h;

DOI:10.1002/ejoc.200601107

Reference yield: 96.0%

benzyl bromide (100-39-0) + trimethylsilylacetylene (1066-54-2) → ethynylsulfanylmethylbenzene (18212-32-3)

Guidance literature:

trimethylsilylacetylene; With n-butyllithium; sulfur; In diethyl ether; hexane; at -78 - 10 ℃;

benzyl bromide; In diethyl ether; hexane; at 10 ℃; Further stages.;

DOI:10.1021/ja994134s

Reference yield:

dibenzyl disulphide (150-60-7) + 1,1-Dichloroethylene (75-35-4,9002-85-1) → ethynylsulfanylmethylbenzene (18212-32-3) + ({[(Z)-2-(benzylsulfanyl)ethenyl]sulfanyl}methyl)benzene (16906-37-9) + ({[(E)-2-(benzylsulfanyl)ethenyl]sulfanyl}methyl)benzene (788-26-1)

Guidance literature:

dibenzyl disulphide; With hydrazine hydrate; potassium hydroxide; at 80 - 86 ℃; for 2h;

1,1-Dichloroethylene; at 25 ℃; for 6h;

DOI:10.1134/S107042801708005X

upstream raw materials:

1,2,3-thiadiazole

benzyl chloride

benzyl trimethylsilylethynyl sulfide

benzyl bromide

Downstream raw materials:

3-benzylthio-2-benzylthioethynylbenzo[b]thiophene

bis(benzylsulfanyl)acetylene

1-(benzylthio)vinyl diphenyl phosphate

C₁₃H₁₃NO₃S

Refernces

• 1、 -. "HETEROARYL PLASMA KALLIKREIN INHIBITORS". Paragraph 0248; 0251-0253. . Retrieved 2021/03/19.
• 2、 Levanova,Nikonova,Rosentsveig,Russavskaya,Albanov,Korchevin. "Synthesis of unsaturated organochalcogen compounds proceeding from dichloroethenes and organyl dichalcogenides". . p. 1186 - 1190. Retrieved 2017/09/29.