N²-<(R)-N²-benzoyl-2-methyl-phenylalanyl>-(S)-phenylalanine cyclohexylamide

Base Information

• Chemical Name: N²-<(R)-N²-benzoyl-2-methyl-phenylalanyl>-(S)-phenylalanine cyclohexylamide
• CAS No.: 169566-66-9
• Molecular Formula: C₃₂H₃₇N₃O₃
• Molecular Weight: 511.664
• Mol file: 169566-66-9.mol

Synonyms:N²-<(R)-N²-benzoyl-2-methyl-phenylalanyl>-(S)-phenylalanine cyclohexylamide

Chemical Property of N²-<(R)-N²-benzoyl-2-methyl-phenylalanyl>-(S)-phenylalanine cyclohexylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N²-<(R)-N²-benzoyl-2-methyl-phenylalanyl>-(S)-phenylalanine cyclohexylamide

There total 1 articles about N²-<(R)-N²-benzoyl-2-methyl-phenylalanyl>-(S)-phenylalanine cyclohexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.4%

rac-4-benzyl-4-methyl-2-phenyl-1,3-oxazol-5(4H)-one (55686-06-1) + L-phenylalanine cyclohexylamide (17186-53-7,92698-80-1) → N2-<(R)-N2-benzoyl-2-methyl-phenylalanyl>-(S)-phenylalanine cyclohexylamide (169566-66-9) + N2-<(S)-N2-benzoyl-2-methyl-phenylalanyl>-(S)-phenylalanine cyclohexylamide

Guidance literature:

In various solvent(s); at 70 ℃; for 24h;

DOI:10.1002/hlca.19950780305

Reference yield: 95.9%

N2-<(R)-N2-benzoyl-2-methyl-phenylalanyl>-(S)-phenylalanine cyclohexylamide (169566-66-9) → (R)-methyl 2-benzamido-2-methyl-3-phenylpropanoate (169738-76-5)

Guidance literature:

With trifluorormethanesulfonic acid; In methanol; at 80 ℃; for 20h;

DOI:10.1002/hlca.19950780305

Reference yield: 70.0%

methanol (67-56-1) + N2-<(R)-N2-benzoyl-2-methyl-phenylalanyl>-(S)-phenylalanine cyclohexylamide (169566-66-9) → (R)-methyl 2-benzamido-2-methyl-3-phenylpropanoate (169738-76-5)

Guidance literature:

With trifluorormethanesulfonic acid; at 80 ℃; for 20h;

DOI:10.1016/S0968-0896(00)00006-7

upstream raw materials:

rac-4-benzyl-4-methyl-2-phenyl-1,3-oxazol-5(4H)-one

L-phenylalanine cyclohexylamide

Downstream raw materials:

(R)-methyl 2-benzamido-2-methyl-3-phenylpropanoate

(R)-2-amino-2-methyl-3-phenylpropanoic acid

α-methyl-DL-phenylalanine methyl ester hydrochloride

(R)-methyl hippuryl-α-methylphenylalaninate