Chemical Property of Isopropyl Myristate
Chemical Property:
- Appearance/Colour:colourless liquid of low viscosity
- Vapor Pressure:0.000329mmHg at 25°C
- Melting Point:-5 °C
- Refractive Index:n20/D 1.434(lit.)
- Boiling Point:319.9 °C at 760 mmHg
- Flash Point:144.1 °C
- PSA：26.30000
- Density:0.864 g/cm3
- LogP:5.63910
- Storage Temp.:2-8°C
- Solubility.:<0.05mg/l
- Water Solubility.:Miscible with alcohol. Immiscible with water and glycerol.
- XLogP3:7.2
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:14
- Exact Mass:270.255880323
- Heavy Atom Count:19
- Complexity:199
- Purity/Quality:
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Isopropyl Myristate *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Chemical Classes:Other Uses -> Emulsifiers/Surfactants
- Canonical SMILES:CCCCCCCCCCCCCC(=O)OC(C)C
- Recent EU Clinical Trials:Randomised, double-blind, bilateral comparison of two emollients in patients with dry skin
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Uses
Isopropyl myristate (IPM) is a fatty acid ester which is used as solvent in water-in-oil emulsion, oils and fatty based ointments. The use of IPM is recommended in the Sterility Test chapter of the European, Japanese and United States Pharmacopoeia (EP, 2.6.13, JP, 4.06 and USP, 71) as diluent for oils and oily solutions, as well as for ointments and creams. Indeed, its solvent properties improve the filterability of these samples.Isopropyl myristate is known as a penetration enhancer for topical preparations. It is a waterclear, low viscous oily liquid with a very good spreading capacity on the skin. Isopropyl Myristate is mainly used in cosmetics as an oilcomponent for emulsions, bath oils and as a solvent for active substances. Isopropyl myristate is an emollient in cosmetic and pharmaceutical bases. In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) . isopropyl myristate is an emollient, moisturizer, binder, and skin softener that also assists in product penetration. An ester of myristic acid, it is naturally occurring in coconut oil and nutmeg. Although isopropyl myristate is generally considered comedogenic, some ingredient manufacturers clearly specify non-comedogenicity on their data sheets.
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Production Method
It is a product of esterification of myristic acid derived from re-steamed coconut coil with isopropyl alcohol.
(1)? 200 kg myristic acid and 450 kg isopropyl alcohol were added into the reaction vessel in turn. After mixing, 360 kg sulfuric acid (98%) was added. The reaction mixture was heated to reflux for 10 hours. Isopropyl alcohol was then recovered, washed with ice water, and neutralized with Na2CO3 aqueous solution (10%). Under normal pressure, isopropyl alcohol and water were distilled. While under reduced pressure, isopropyl myristate was distilled (185°C/1.0kPa~195°C/2.7kPa).
(2) 90 kg isopropyl alcohol was added into the reaction vessel and then sulfuric acid as catalyst, with 5% of the total amount, was added. During mixing, 228 kg myristic acid was added slowly. The mixture was heated to reflux and water was continuously separated. Until no water was separated, the reaction temperature was reduced and probe was obtained to measure the acid value. When the acid value reached 1.5 mg KOH/g, the reaction was completed. Alkali was then added for neutralization. After the removal of water under reduced pressure, the pressure was further reduced for dealcoholization until the acid value was 0.05~1.0 mg KOH/g. The final product is then isopropyl myristate.
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Description
Isopropyl myristate is odorless when pure. May be synthesized by
conventional esterification of isopropanol with myristic acid.
